*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : BD6195000
CHEMICAL NAME : alpha-Amanitine
CAS REGISTRY NUMBER : 23109-05-9
OTHER CAS REGISTRY NOS. : 21150-20-9
21373-20-6
BEILSTEIN REFERENCE NO. : 1071138
LAST UPDATED : 199612
DATA ITEMS CITED : 23
MOLECULAR FORMULA : C39-H54-N10-O14-S
MOLECULAR WEIGHT : 919.09
WISWESSER LINE NOTATION : T C6 B5 R5-18--18-/MP& A K L 2BJ P& IM KS NVM QVN WVM
C&VM F&VM I&VM L&VM O&VM&&TTTJ FQ KO P1
COMPOUND DESCRIPTOR : Mutagen
Natural Product
SYNONYMS/TRADE NAMES :
* alpha-Amanitin
* alpha-Amatoxin
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 100 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10
Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year:
269,223,1963
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag,
Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
Volume(issue)/page/year: 22,2142,1972
** MUTATION DATA **
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 700 mg/L
REFERENCE :
AMICCW Archives of Microbiology. (Springer-Verlag New York, Inc., Service
Center, 44 Hartz Way, Secacus, NJ 07094) V.95- 1974-
Volume(issue)/page/year: 122,161,1979
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 500 mg/L
REFERENCE :
AMICCW Archives of Microbiology. (Springer-Verlag New York, Inc., Service
Center, 44 Hartz Way, Secacus, NJ 07094) V.95- 1974-
Volume(issue)/page/year: 122,161,1979
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 125 mg/L
REFERENCE :
AMICCW Archives of Microbiology. (Springer-Verlag New York, Inc., Service
Center, 44 Hartz Way, Secacus, NJ 07094) V.95- 1974-
Volume(issue)/page/year: 118,317,1978
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 250 ug/L
REFERENCE :
AMICCW Archives of Microbiology. (Springer-Verlag New York, Inc., Service
Center, 44 Hartz Way, Secacus, NJ 07094) V.95- 1974-
Volume(issue)/page/year: 118,317,1978
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Insect - Drosophila melanogaster Cells - not
otherwise specified
DOSE/DURATION : 20 mg/L
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 15,973,1977
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Insect - not otherwise specified Cells - not
otherwise specified
DOSE/DURATION : 10 ug
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211,
1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year:
697,213,1982
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 20 mg/L
REFERENCE :
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information
Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
Volume(issue)/page/year: 20,103,1982
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 1 mg/kg
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211,
1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year:
782,262,1984
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 1 mg/L
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211,
1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year:
654,31,1981
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - rat Kidney
DOSE/DURATION : 1 mg/L
REFERENCE :
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211,
1000 AE Amsterdam, Netherlands) V.1- 1947- Volume(issue)/page/year:
654,31,1981
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 100 nmol/L
REFERENCE :
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW,
UK) V.1- 1962- Volume(issue)/page/year: 25,1265,1987
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 500 ug/kg
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 67,311,1971
TYPE OF TEST : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 500 ug/kg
REFERENCE :
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce
Way, Colchester, Essex CO2 8HP, UK) V.1- 1906- Volume(issue)/page/year:
105,779,1967
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - mouse Ascites tumor
DOSE/DURATION : 2 mg/L
REFERENCE :
JANTAJ Journal of Antibiotics. (Japan Antibiotics Research Assoc., 2-20-8
Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan) V.2-5, 1948-52; V.21- 1968-
Volume(issue)/page/year: 36,155,1983
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 500 ug/kg
REFERENCE :
ECREAL Experimental Cell Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.10- 1950- Volume(issue)/page/year: 67,311,1971
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Bird - chicken Fibroblast
DOSE/DURATION : 100 mg/L
REFERENCE :
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000
Berlin 33, Fed. Rep. Ger.) V.1- 1913- Volume(issue)/page/year:
59,368,1972
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Non-mammalian species Ovary
DOSE/DURATION : 500 ug/L
REFERENCE :
CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44
Hartz Way, Secaucus, NJ 07094) V.1- 1939- Volume(issue)/page/year:
82,171,1981
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - rabbit Bone marrow
DOSE/DURATION : 100 ug/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
50,203,1984
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Rodent - rabbit Cells - not otherwise specified
DOSE/DURATION : 250 ug/L
REFERENCE :
AMICCW Archives of Microbiology. (Springer-Verlag New York, Inc., Service
Center, 44 Hartz Way, Secacus, NJ 07094) V.95- 1974-
Volume(issue)/page/year: 118,317,1978
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Mammal - cattle Liver
DOSE/DURATION : 3 mg/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
56,289,1985
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster-whole sex chrom. loss
*** END OF RECORD ***