*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BD9115000
CHEMICAL NAME           : Ambistrin
CAS REGISTRY NUMBER     : 8017-59-2
LAST UPDATED            : 198910
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C21-H41-N7-O12.C21-H39-N7-O12
MOLECULAR WEIGHT        : 1165.36
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
                          Human
SYNONYMS/TRADE NAMES :
   * Dihydrostreptomycin and streptomycin
   * Duo-streptomycin
   * Streptomycin and dihydrostreptomycin
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 540 mg/kg
SEX/DURATION            : female 27-39 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - eye/ear
   Reproductive - Effects on Newborn - other neonatal measures or effects
REFERENCE :
   SJRDAH Scandinavian Journal of Respiratory Diseases.  (Copenhagen, Denmark)
   V.47-60, 1966-79. Discontinued.  Volume(issue)/page/year: 50,101,1969
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 560 mg/kg
SEX/DURATION            : female 1-10 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
   SJRDAH Scandinavian Journal of Respiratory Diseases.  (Copenhagen, Denmark)
   V.47-60, 1966-79. Discontinued.  Volume(issue)/page/year: 50,101,1969
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 540 mg/kg
SEX/DURATION            : female 22-37 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
   SJRDAH Scandinavian Journal of Respiratory Diseases.  (Copenhagen, Denmark)
   V.47-60, 1966-79. Discontinued.  Volume(issue)/page/year: 50,61,1969
 
                            *** END OF RECORD ***