*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : BD9638000 CHEMICAL NAME : Ambros-2-en-12-oic acid, 6-alpha,8-beta-dihydroxy-4-oxo-, 12,8-lactone, (11S)- CAS REGISTRY NUMBER : 34257-95-9 LAST UPDATED : 198606 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C15-H20-O4 MOLECULAR WEIGHT : 264.35 COMPOUND DESCRIPTOR : Drug Mutagen SYNONYMS/TRADE NAMES : * Dihydrohelenalin * 11,13-Dihydrohelenalin * Plenolin *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 123 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 45,131,1982 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 31 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953- Volume(issue)/page/year: 45,131,1982 ** MUTATION DATA ** TYPE OF TEST : DNA inhibition TEST SYSTEM : Rodent - mouse Ascites tumor DOSE/DURATION : 2143 umol/L REFERENCE : JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 67,1235,1978 *** END OF RECORD ***