*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : BP0693200
CHEMICAL NAME           : Ammonium,
                          (3-carbamoyl-3,3-diphenylpropyl)diisopropylmethyl-,
                          iodide
CAS REGISTRY NUMBER     : 71-81-8
LAST UPDATED            : 199806
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C23-H33-N2-O.I
MOLECULAR WEIGHT        : 480.48
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * (3-Carbamoyl-3,3-diphenylpropyl)diisopropylmethylammonium iodide
   * Darbid
   * 2,2-Diphenyl-4-diisopropylaminobutyramide methiodide
   * Dipramid
   * Dipramide
   * Isamid
   * Isopropamide iodide
   * Marygin-M
   * 5579 MD
   * Piaccamide
   * Priamide
   * Priazimide
   * R 79
   * Sanulcin
   * SKF 4740
   * Tyrimide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: -,1318,1995
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1600 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Sense Organs and Special Senses (Eye) - lacrimation
   Autonomic Nervous System - parasympatholytic
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 103,120,1955
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 120 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation)
   Sense Organs and Special Senses (Eye) - lacrimation
   Autonomic Nervous System - parasympatholytic
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 103,120,1955
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 12779 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 103,100,1955

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M4907
       No. of Facilities: 200 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 801 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M4907
       No. of Facilities: 68 (estimated)
       No. of Industries: 1
       No. of Occupations: 1
       No. of Employees: 690 (estimated)
       No. of Female Employees: 414 (estimated)

 
                            *** END OF RECORD ***