*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : QJ6420000
CHEMICAL NAME : 2,7-Naphthalenedisulfonic acid,
3,3'-((3,3'-dimethoxy-4,4'-biphenylylene)bis(azo))bis
( 5-amino-4-hydroxy-, tetrasodium salt
CAS REGISTRY NUMBER : 2429-74-5
OTHER CAS REGISTRY NOS. : 51568-94-6
95032-75-0
LAST UPDATED : 199710
DATA ITEMS CITED : 19
MOLECULAR FORMULA : C34-H24-N6-O16-S4.4Na
MOLECULAR WEIGHT : 992.84
WISWESSER LINE NOTATION : L66J BQ DSWO HSWO JZ CNUNR CO1 DR BO1 DNUN- CL66J BQ
DSWO HSWO JZ &-NA- 4
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Airedale Blue D
* Aizen Direct Sky Blue 5B
* Aizen Direct Sky Blue 5BH
* Amanil Sky Blue
* Atlantic Sky Blue A
* Atul Direct Sky Blue
* Azine Sky Blue 5B
* Belamine Sky Blue A
* Benzanil Sky Blue
* Benzo Sky Blue S
* Benzo Sky Blue A-CF
* Cartasol Blue 2GF
* Chloramine Sky Blue A
* Chloramine Sky Blue 4B
* Chrome Leather Pure Blue
* C.I. 24400
* C.I. Direct Blue 15
* C.I. Direct Blue 15, tetrasodium salt
* Cresotine Pure Blue
* Diacotton Sky Blue 5B
* Diamine Blue
* Diamine Blue 6B
* Diamine Sky Blue
* Diamine Sky Blue CI
* Diaphtamine Pure Blue
* Diazol Pure Blue 4B
* Diphenyl Brilliant Blue
* Diphenyl Sky Blue 6B
* Direct Blue 15
* Direct Blue 10G
* Direct Blue HH
* Direct Pure Blue
* Direct Pure Blue M
* Direct Sky Blue A
* Direct Sky Blue 5B
* Enianil Pure Blue AN
* Fenamin Sky Blue
* Hispamin Sky Blue 3B
* Kayafect Blue Y
* Kayaku Direct Sky Blue 5B
* Mitsui Direct Sky Blue 5B
* Modr Prima 15
* Naphtamine Blue 10G
* NCI C61290
* Niagara Blue 4B
* Niagara Sky Blue
* Nippon Direct Sky Blue
* Nippon Sky Blue
* Nitto Direct Sky Blue 5B
* Oxamine Sky Blue 5B
* Paper Blue S
* Phenamine Sky Blue A
* Pontamine Sky Blue 5BX
* Pontacyl Sky Blue 4BX
* Shikiso Direct Sky Blue 5B
* Sky Blue 4B
* Sky Blue 5B
* Tertrodirect Blue F
* Vondacel Blue HH
*** HEALTH HAZARD DATA ***
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 52500 mg/kg/14D-C
TOXIC EFFECTS :
Liver - other changes
Endocrine - changes in thymus weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-397,1992
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 gm/kg/13W
TOXIC EFFECTS :
Liver - fatty liver degeneration
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-397,1992
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 168 gm/kg/96W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Brain and Coverings - tumors
Blood - leukemia
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-397,1992
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 70 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
resorbed implants per total number of implants)
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 127,215,1968
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 200 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
Reproductive - Specific Developmental Abnormalities - eye/ear
REFERENCE :
PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
(Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
Volume(issue)/page/year: 127,215,1968
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE : 140 mg/kg
SEX/DURATION : female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
TJADAB Teratology, The International Journal of Abnormal Development. (Alan
R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
Volume(issue)/page/year: 2,85,1969
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE : 5 gm/kg
SEX/DURATION : female 8-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - other postnatal measures or effects
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
20,177,1993
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 500 ug/plate
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and
Comparative Toxicology, Publication Office, Comparative Toxicology,
Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 22,413,1980
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 100 ug/plate
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 18,111,1986
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 57,235,1993
IARC Cancer Review:Human Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 57,235,1993
IARC Cancer Review:Group 2B
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 57,235,1993
TOXICOLOGY REVIEW
ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72.
Discontinued. Volume(issue)/page/year: 1,131,1966
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M4514
No. of Facilities: 10 (estimated)
No. of Industries: 1
No. of Occupations: 2
No. of Employees: 69 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M4514
No. of Facilities: 485 (estimated)
No. of Industries: 7
No. of Occupations: 7
No. of Employees: 4527 (estimated)
No. of Female Employees: 201 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NTP Carcinogenesis Studies (drinking);clear evidence:rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-397,92
*** END OF RECORD ***