*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QJ6475500
CHEMICAL NAME           : 1,3-Naphthalenedisulfonic acid,
                          8-((3,3'-dimethyl-4'-((4-(((4-methylphenyl)sulfonyl)o
                          xy) phenyl)azo)(1,1'-biphenyl)-4-yl)azo)-7-hydroxy-,
                          disodium salt
CAS REGISTRY NUMBER     : 6459-94-5
LAST UPDATED            : 199710
DATA ITEMS CITED        : 14
MOLECULAR FORMULA       : C37-H28-N4-O10-S3.2Na
MOLECULAR WEIGHT        : 830.85
WISWESSER LINE NOTATION : L66J BNUNR B1 DR C1 DNUNR DOSWR D1&&&& CQ HSWO JSWO
                          &-NA- 2
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Acid Leather Red BG
   * Acid Red 114
   * Amacid Milling Red PRS
   * Benzyl Fast Red BG
   * Benzyl Red BR
   * Cerven kysela 114
   * C.I. 23635
   * C.I. Acid Red 114
   * C.I. Acid Red 114, disodium salt
   * Elcacid Milling Fast Red RS
   * Erionyl Red RS
   * Fenafor Red PB
   * Folan Red B
   * Intrazone Red BR
   * Kayanol Milling Red RS
   * Leather Fast Red B
   * Levanol Red GG
   * Midlon Red PRS
   * Milling Fast Red B
   * Milling Red B
   * Milling Red BB
   * Milling Red SWB
   * NCI C61096
   * Polar Red RS
   * Sandolan Red N-RS
   * Sella Fast Red RS
   * Sulphonol Fast Red R
   * Sulphonol Red R
   * Suminol Milling Red RS
   * Supranol Fast Red 3G
   * Supranol Fast Red GG
   * Supranol Red PBX-CF
   * Supranol Red R
   * Telon Fast Red GG
   * Tetracid Milling Red B
   * Tetracid Milling Red G
   * Vondamol Fast Red RS
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 26 gm/kg/13D-C
TOXIC EFFECTS :
   Endocrine - changes in thymus weight
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NPT-TR-405,1991
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10920 mg/kg/13W-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Kidney, Ureter, Bladder - changes in bladder weight
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - transaminases
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-405,1991
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 15 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
   Skin and Appendages - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-405,1991
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 300 nmol/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 136,33,1984
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 125 ug/plate
REFERENCE :
   VHTODE Veterinary and Human Toxicology.  (American College of Veterinary and
   Comparative Toxicology, Publication Office, Comparative Toxicology,
   Manhattan, KS 66506)  V.19-    1977-  Volume(issue)/page/year: 22,413,1980

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Sufficient Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 57,247,1993

   IARC Cancer Review:Human Inadequate Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 57,247,1993

   IARC Cancer Review:Group 2B
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 57,247,1993

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M1427
       No. of Facilities: 116 (estimated)
       No. of Industries: 3
       No. of Occupations: 14
       No. of Employees: 2855 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M1427
       No. of Facilities: 331 (estimated)
       No. of Industries: 9
       No. of Occupations: 12
       No. of Employees: 18511 (estimated)
       No. of Female Employees: 352 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   EPA TSCA Section 8(d) unpublished health/safety studies
   
   EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
   
   NTP Carcinogenesis Studies (drinking);clear evidence:rat
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-405,91

 
                            *** END OF RECORD ***