*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : QJ6500000
CHEMICAL NAME : 1,3-Naphthalenedisulfonic acid,
7-hydroxy-8-(phenylazo)-, disodium salt
CAS REGISTRY NUMBER : 1936-15-8
LAST UPDATED : 199707
DATA ITEMS CITED : 17
MOLECULAR FORMULA : C16-H10-N2-O7-S2.2Na
MOLECULAR WEIGHT : 452.38
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Acidal Fast Orange
* Acid Fast Orange EGG
* Acid Fast Orange G
* Acid Leather Orange KG
* Acid Leather Orange PGW
* Acid Light Orange G
* Acid Light Orange J
* Acid Light Orange JA Export
* Acid Light Orange SX
* Acid Orange 10
* Acid Orange G
* Acid Orange 2G
* Acid Orange GG
* Acilan Orange GX
* Apocid Orange 2G
* Atul Acid Crystal Orange G
* Brasilan Orange 2G
* Bucacid Fast Orange G
* Calcocid Fast Light Orange 2G
* Certicol Orange GS
* Cetil Light Orange GG
* C.I. 27
* C.I. 16230
* C.I. Acid Orange 10
* C.I. Acid Orange 10, disodium salt
* C.I. Food Orange 4
* Colacid Orange G
* Crystal Orange 2G
* D&C Orange No. 3
* Eniacid Light Orange G
* Erio Fast Orange AS
* Fast Light Orange GA
* Fast Light Orange GA-CF
* Hexacol Orange GG Crystals
* Hidacid Fast Orange G
* Hidacid Fast Orange 2G
* Hispacid Fast Orange 2G
* 7-Hydroxy-8-(phenylazo)-1,3-naphthalenedisulfonic acid, disodium salt
* 7-Hydroxy-8-(phenylazo)-1,3-naphthalenedisulphonic acid, disodium salt
* Java Orange 2G
* Kiton Fast Orange G
* Ink Orange JSN
* Intracid Fast Orange G
* Naphthalene Fast Orange 2G
* Naphthalene Fast Orange 2GS
* Naphthalene Orange Solide GG
* NCI-C53838
* Neklacid Fast Light Orange GG
* Neklacid Fast Orange 2G
* Orange #10
* 1370 Orange
* Orange BPC
* Orange 2G
* Orange G (biological stain)
* Orange G BPC
* Orange G DYE
* Orange GG
* Orange G (indicator)
* Orange GMP
* Oranz G
* Oranz GG
* Oranz kysela 10
* Oranz potravinarska 4
* 1-Phenylazo-2-naphthol-6,8-disulfonic acid, disodium salt
* 1-Phenylazo-2-naphthol-6,8-disulphonic acid, disodium salt
* Schultz No. 39
* Solar Light Orange GX
* Standacol Orange G
* Straight Orange G
* Sulfacid Light Orange J
* Tertracid Light Orange G
* Unitertracid Light Orange G
* Vondacid Light Orange 2G
* Wool Orange G
* Wool Orange 2G
* Xylene Fast Orange G
*** HEALTH HAZARD DATA ***
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 26250 mg/kg/15W-C
TOXIC EFFECTS :
Liver - changes in liver weight
Endocrine - changes in spleen weight
Blood - normocytic anemia
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 9,329,1971
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 27300 mg/kg/13W-C
TOXIC EFFECTS :
Blood - changes in spleen
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-211,1987
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 136 gm/kg/13W-C
TOXIC EFFECTS :
Blood - changes in spleen
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-211,1987
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - pig
DOSE/DURATION : 2800 mg/kg/16W-C
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Blood - normocytic anemia
Blood - other changes
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,367,1973
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - pig
DOSE : 28 gm/kg
SEX/DURATION : male 16 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 11,367,1973
** MUTATION DATA **
TYPE OF TEST : Phage inhibition capacity
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 100 mmol/L
REFERENCE :
MDMIAZ Medycyna Doswiadczalna i Mikrobiologia. For English translation, see
EXMMAV. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1949-
Volume(issue)/page/year: 31,11,1979
TYPE OF TEST : Specific locus test
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 1 gm/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
17,196,1991
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 1250 mg/L
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
14,165,1989
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 20 umol/L/5H (Continuous)
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979
*** REVIEWS ***
IARC Cancer Review:Animal Inadequate Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 8,181,1975
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 8,181,1975
IARC Cancer Review:Group 3
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M2138
No. of Facilities: 613 (estimated)
No. of Industries: 9
No. of Occupations: 24
No. of Employees: 11575 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M2138
No. of Facilities: 588 (estimated)
No. of Industries: 11
No. of Occupations: 32
No. of Employees: 27936 (estimated)
No. of Female Employees: 12401 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; Histidine
reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP Carcinogenesis Studies (feed);no evidence:mouse,rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-211,87
*** END OF RECORD ***