*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : QJ6530000
CHEMICAL NAME : 2,7-Naphthalenedisulfonic acid,
3-hydroxy-4-((4-sulfo-1-naphthalenyl)azo)-, trisodium
salt
CAS REGISTRY NUMBER : 2611-82-7
OTHER CAS REGISTRY NOS. : 39470-82-1
LAST UPDATED : 199709
DATA ITEMS CITED : 16
MOLECULAR FORMULA : C20-H14-N2-O10-S3.3Na
MOLECULAR WEIGHT : 607.51
WISWESSER LINE NOTATION : L66J CO HSWO JSWO BNUN- BL66J ESWO &-NA- 4
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* Acidal Bright Ponceau 3R
* Acid Brilliant Scarlet 3R
* Acid Ponceau 4R
* Acid Red 18
* Acid Scarlet 3R
* Acid Scarlet 4R
* Acid Scarlet 3RZ
* Acilan Scarlet V3R
* Aizen Brilliant Scarlet 3RH
* Atul Acid Scarlet 3R
* Atul Scarlet F
* Brilliant Ponceau 3R
* Brilliant Ponceau 4R
* Brilliant Ponceau 5R
* Brilliant Ponceau 4RC
* Brilliant Ponceau 4RC Specially Pure
* Brilliant Ponceau 3RF
* Brilliant Scarlet
* Brilliant Scarlet 3R
* Brilliant Scarlet 4R
* Bucacid Brilliant Scarlet 3R
* Calcocid Brilliant Scarlet 3RN
* Certicol Ponceau 4RS
* Cerven kosenilova A
* Cerven kysela 18
* Cerven potravinarska 7
* Cilefa Ponceau 4R
* Coccine
* Coccine nouvelle
* Coccin Red
* Cochenillerot A
* Cochineal Red A
* Cochineal Red A Specially Pure
* Cochineal Red 4R
* Colacid Ponceau 4R
* C.I. 185
* C.I. 16255
* C.I. Acid Red 18
* C.I. Acid Red 18, trisodium salt
* C.I. Food Red 7
* Crimson SX
* Curol Bright Red 4R
* Daishiki Brilliant Scarlet 3R
* E 124
* Edicol Supra Ponceau 4R
* Eurocert Cochineal Red A
* Fenazo Scarlet 3R
* Food Red 6
* Food Red 7
* Food Red No. 102
* HD Ponceau 4R
* HD Ponceau 4R Supra
* Hexacol Ponceau 4R
* Hidacid Fast Scarlet 3R
* Hispacid Brilliant Scarlet 3RF
* Java Scarlet 3R
* Kayaku Acid Brilliant Scarlet 3R
* Kayaku Food Colour Red No. 102
* Kiton Scarlet 4R
* Kochineal Red A for food
* L-Rot 4
* Naphthalene Ink Scarlet 4R
* Naphthalene Scarlet 4R
* Naphthalene Scarlet 4RS
* Neklacid Red 3R
* Neklacid Red 4R
* Neucoccin
* New coccin
* New coccine
* New Coccine Extra Conc. A Export
* New Coccine Extra Pure A
* Ponceau 4R
* Ponceau 4R Aluminum Lake
* Ponceau 4RE
* Ponceau 4RE.FQ
* Ponceau 4RF
* Ponceau 4RT
* Pontacyl Scarlet RR
* Purple Red
* Purple SX
* Rakuto Brilliant Scarlet 3R
* 1578 Red
* Rouge de cochenille A
* San-ei Brilliant Scarlet 3R
* Schultz Nr. 213
* Strawberry Red A Geigy
* Sugai Brilliant Scarlet 3R
* 1-(4-Sulpho-1-naphthylazo)-2-naphthol-6,8-disulphonic acid, trisodium
salt
* SX purple
* Symulon Acid Brilliant Scarlet 3R
* Takaoka Brilliant Scarlet 3R
* Victoria Scarlet 3R
* Victoria Scarlet Red
* Victoria Scharlach 4 R Extra
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >8 gm/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 5,187,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 600 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 5,187,1967
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCPHA4 Scientia Pharmaceutica. (Oesterreichische
Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria)
V.1- 1930- Volume(issue)/page/year: 47,39,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Unreported
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NAIZAM Nara Igaku Zasshi. Journal of the Nara Medical Association. (Nara
Igakkai, c/o Narakenritsu Ika Daigaku, Shijo-cho, Kashihara, Nara-ken,
Japan) V.1- 1950- Volume(issue)/page/year: 30,179,1979
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SCPHA4 Scientia Pharmaceutica. (Oesterreichische
Apotheker-Verlagsgesellschaft MBH, Spitalgasse 31, 1094 Vienna 9, Austria)
V.1- 1930- Volume(issue)/page/year: 47,39,1979
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1600 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - convulsions or effect on seizure threshold
Behavioral - coma
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 5,187,1967
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 143 gm/kg/90D-C
TOXIC EFFECTS :
Blood - pigmented or nucleated red blood cells
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - transaminases
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 5,187,1967
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 30 gm/kg/30D-I
TOXIC EFFECTS :
Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
acute tubular necrosis)
Kidney, Ureter, Bladder - other changes in urine composition
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479,
Russia) History Unknown Volume(issue)/page/year: (2),34,1996
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 48 mg/m3/17W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in trachea
or bronchi
Liver - liver function tests impaired
Blood - other changes
REFERENCE :
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479,
Russia) History Unknown Volume(issue)/page/year: (2),34,1996
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 428 gm/kg/64W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Liver - tumors
REFERENCE :
VPITAR Voprosy Pitaniya. Problems of Nutrition. (V/O Mezhdunarodnaya
Kniga, 113095 Moscow, USSR) V.1-10, 1932-41; V.11- 1952-
Volume(issue)/page/year: 29,61,1970
** MUTATION DATA **
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 1 gm/L
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year:
22,623,1984
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - M4494
No. of Facilities: 46 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 138 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - M4494
No. of Facilities: 1035 (estimated)
No. of Industries: 5
No. of Occupations: 9
No. of Employees: 8379 (estimated)
No. of Female Employees: 2006 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
EPA TSCA Section 8(b) CHEMICAL INVENTORY
*** END OF RECORD ***