*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : QJ6650000
CHEMICAL NAME : 2,7-Naphthalenedisulfonic acid,
3-hydroxy-4-((2,4,5-trimethylphenyl)azo)-, disodium
salt
CAS REGISTRY NUMBER : 3564-09-8
LAST UPDATED : 199709
DATA ITEMS CITED : 19
MOLECULAR FORMULA : C19-H16-N2-O7-S2.2Na
MOLECULAR WEIGHT : 494.47
WISWESSER LINE NOTATION : L66J BNUNR B1 D1 E1& CQ DSWQ HSWQ &-NA- 2
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
SYNONYMS/TRADE NAMES :
* A.F. Red No. 1
* Cerven kumidinova
* Cerven potravinarska 6
* C.I. 16155
* C.I. Food Red 6
* C.I. Food Red 6, disodium salt
* Disodium
3-hydroxy-4-((2,4,5-trimethylphenyl)azo)-2,7-naphthalenedisulfonate
* Disodium
3-hydroxy-4-((2,4,5-trimethylphenyl)azo)-2,7-naphthalenedisulphonate
* Dolkwal Ponceau 3R
* Ext D and C Red No. 15
* FD and C Red No. 1
* 3-Hydroxy-4-((2,4,5-trimethylphenyl)azo)-2,7-naphthalenedisulphonic acid,
disodium salt
* Maple Ponceau 3R
* Ponceau 3R
* Ponceau RN
* Ponceau 3R Lake
* Ponceau 3RN
* Ponceau 3R sodium salt
* Sodium cumeneazo-beta-naphthol disulfonate
* Sodium cumeneazo-beta-naphthol disulphonate
* Usacert Red No. 1
*** HEALTH HAZARD DATA ***
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 730 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
5,105,1963
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1640 gm/kg/65W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Liver - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
3,509,1961
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - tumors
REFERENCE :
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills,
Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year:
17,127,1963
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1140 gm/kg/68W-C
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Liver - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
5,105,1963
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 200 gm/kg/24W-C
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Liver - tumors
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
5,105,1963
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 660 nmol/plate
REFERENCE :
INFIBR Infection and Immunity. (American Soc. for Microbiology, 1913 I St.,
NW, Washington, DC 20006) V.1- 1970- Volume(issue)/page/year:
23,686,1979
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 300 umol/L
REFERENCE :
SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin
Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo
150, Japan) V.1- 1960- Volume(issue)/page/year: 12,298,1971
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Rodent - mouse Lymphocyte
DOSE/DURATION : 1701 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 189,223,1987
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 8,199,1975
IARC Cancer Review:Human No Adequate Data
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 8,199,1975
IARC Cancer Review:Group 2B
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49
Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year:
7,56,1987
TOXICOLOGY REVIEW
ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For
publisher information, see ARPTDI. Volume(issue)/page/year: 14,127,1974
TOXICOLOGY REVIEW
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 83806
No. of Facilities: 131 (estimated)
No. of Industries: 2
No. of Occupations: 3
No. of Employees: 827 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 83806
No. of Facilities: 3 (estimated)
No. of Industries: 1
No. of Occupations: 1
No. of Employees: 36 (estimated)
No. of Female Employees: 16 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
*** END OF RECORD ***