*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : QJ6825000 CHEMICAL NAME : 2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-(2,4-xylylazo)-, disodium salt CAS REGISTRY NUMBER : 3761-53-3 LAST UPDATED : 199707 DATA ITEMS CITED : 20 MOLECULAR FORMULA : C18-H14-N2-O7-S2.2Na MOLECULAR WEIGHT : 480.44 WISWESSER LINE NOTATION : L66J BNUNR B1 D1& CQ DSWQ HSWQ &-NA- 2 COMPOUND DESCRIPTOR : Tumorigen Mutagen SYNONYMS/TRADE NAMES : * Acetacid Red J * Acidal Ponceau G * Acid Leather Red KPR * Acid Leather Red P2R * Acid Leather Scarlet IRW * Acid Ponceau R * Acid Ponceau 2RL * Acid Ponceau Special * Acid Red 26 * Acid Scarlet * Acid Scarlet 2B * Acid Scarlet 2BN * Acid Scarlet 2R * Acid Scarlet 2R For Lakes * Acid Scarlet 2R FOR Lakes Bluish * Acid Scarlet 2RL * Acid Scarlet 2RN * Acilan Ponceau RRL * Ahcocid Fast Scarlet R * Aizen Ponceau RH * Amacid Lake Scarlet 2R * Amacid Scarlet 2R * Brilliant Ponceau G * Calcocid 2RIL * Calcocid Scarlet 2R * Calcocid Scarlet 2RIL * Calcolake Scarlet 2R * Certicol Ponceau MXS * Cerven kysela 26 * Cerven potravinarska 5 * C.I. 79 * C.I. 16150 * C.I. Acid Red 26 * C.I. Acid Red 26, disodium salt * C.I. Food Red 5 * Colacid Ponceau Special * Comacid Scarlet 2R * D&C Red No. 5 * 4-((2,4-Dimethylphenyl)azo)-3-hydroxy-2,7-naphthalenedisulfonic acid, disodium salt * 4-((2,4-Dimethylphenyl)azo)-3-hydroxy-2,7-naphthalenedisulphonic acid, disodium salt * Disodium (2,4-dimethylphenylazo)-2-hydroxynaphthalene-3,6-disulfonate * Disodium (2,4-dimethylphenylazo)-2-hydroxynaphthalene-3,6-disulphonate * Disodium salt of 1-(2,4-xylylazo)-2-naphthol-3,6-disulfonic acid * Disodium salt of 1-(2,4-xylylazo)-2-naphthol-3,6-disulphonic acid * Edicol Ponceau RS * Edicol Supra Ponceau R * Fenazo Scarlet 2R * Food Red No. 101 * Hexacol Ponceau MX * Hexacol Ponceau 2R * Hidacid Scarlet 2R * Hispacid Ponceau R * 3-Hydroxy-4-(2,4-xylylazo)-3,7-naphthalenedisulfonic acid, disodium salt * 3-Hydroxy-4-(2,4-xylylazo)-3,7-naphthalenedisulphonic acid, disodium salt * Java Ponceau 2R * Kiton Ponceau R * Kiton Ponceau 2R * Kiton Scarlet 2RC * Lake Ponceau * Lake Scarlet R * Lake Scarlet 2RBN * Naphthalene Lake Scarlet R * Naphthalene Scarlet R * Naphthazine Scarlet 2R * Neklacid Red RR * New Ponceau 4R * Paper Red HRR * Pas kwasowy 2 RL * Pigment Ponceau R * Ponceau BNA * Ponceau de xylidine * Ponceau FR * Ponceau G * Ponceau GR * Ponceau J * Ponceau MX * Ponceau NR * Ponceau PXM * Ponceau R * Ponceau 2R * Ponceau R (biological stain) * Ponceau 2R (biological stain) * Ponceau 2RE * Ponceau Red * Ponceau Red R * Ponceau 2R Extra A Export * Ponceau RG * Ponceau 2RL * Ponceau RS * Ponceau RR * Ponceau RR Type 8019 * Ponceau 2RX * Ponceau xylidine (biological stain) * 1695 Red * Red For Lakes J * Red No. 503 * Scarlet R * Scarlet 2R * Scarlet 2RB * Scarlet 2RL bluish * Scarlet RRA * Schultz No. 95 * Tertracid Ponceau 2R * Xylidine Ponceau * Xylidine Ponceau 3RS * Xylidine Red * 1-Xylylazo-2-naphthol-3,6-disulfonic acid, disodium salt * 1-(2,4-Xylylazo)-2-naphthol-3,6-disulphonic acid, disodium salt * 1-Xylylazo-2-naphthol-3,6-disulphonic acid, disodium salt *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 23160 mg/kg TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - ataxia REFERENCE : BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 21,65,1988 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 4,375,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >6600 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949- Volume(issue)/page/year: 36(1-4),10,1989 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Behavioral - somnolence (general depressed activity) Behavioral - antipsychotic REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 4,375,1966 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1530 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold REFERENCE : SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949- Volume(issue)/page/year: 36(1-4),10,1989 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 45 gm/kg/90D-C TOXIC EFFECTS : Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in spleen weight REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 4,375,1966 ** TUMORIGENIC DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 136 gm/kg/81W-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 6,591,1968 TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 35 gm/kg/52W TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors REFERENCE : BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 10,653,1956 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 100 ug/plate REFERENCE : CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 49,1970,1982 TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Bacteria - Escherichia coli DOSE/DURATION : 300 umol/L REFERENCE : SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo 150, Japan) V.1- 1960- Volume(issue)/page/year: 12,298,1971 TYPE OF TEST : Sister chromatid exchange ROUTE OF EXPOSURE : Intraperitoneal TEST SYSTEM : Rodent - mouse DOSE/DURATION : 63 mg/kg REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 108,225,1983 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,189,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,189,1975 IARC Cancer REIEW:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3143 No. of Facilities: 212 (estimated) No. of Industries: 4 No. of Occupations: 6 No. of Employees: 2142 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3143 No. of Facilities: 131 (estimated) No. of Industries: 3 No. of Occupations: 4 No. of Employees: 1200 (estimated) No. of Female Employees: 874 (estimated) *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; Histidine reversion-Ames test EPA TSCA Section 8(b) CHEMICAL INVENTORY *** END OF RECORD ***