*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QJ6825000
CHEMICAL NAME           : 2,7-Naphthalenedisulfonic acid,
                          3-hydroxy-4-(2,4-xylylazo)-, disodium salt
CAS REGISTRY NUMBER     : 3761-53-3
LAST UPDATED            : 199707
DATA ITEMS CITED        : 20
MOLECULAR FORMULA       : C18-H14-N2-O7-S2.2Na
MOLECULAR WEIGHT        : 480.44
WISWESSER LINE NOTATION : L66J BNUNR B1 D1& CQ DSWQ HSWQ &-NA- 2
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Acetacid Red J
   * Acidal Ponceau G
   * Acid Leather Red KPR
   * Acid Leather Red P2R
   * Acid Leather Scarlet IRW
   * Acid Ponceau R
   * Acid Ponceau 2RL
   * Acid Ponceau Special
   * Acid Red 26
   * Acid Scarlet
   * Acid Scarlet 2B
   * Acid Scarlet 2BN
   * Acid Scarlet 2R
   * Acid Scarlet 2R For Lakes
   * Acid Scarlet 2R FOR Lakes Bluish
   * Acid Scarlet 2RL
   * Acid Scarlet 2RN
   * Acilan Ponceau RRL
   * Ahcocid Fast Scarlet R
   * Aizen Ponceau RH
   * Amacid Lake Scarlet 2R
   * Amacid Scarlet 2R
   * Brilliant Ponceau G
   * Calcocid 2RIL
   * Calcocid Scarlet 2R
   * Calcocid Scarlet 2RIL
   * Calcolake Scarlet 2R
   * Certicol Ponceau MXS
   * Cerven kysela 26
   * Cerven potravinarska 5
   * C.I. 79
   * C.I. 16150
   * C.I. Acid Red 26
   * C.I. Acid Red 26, disodium salt
   * C.I. Food Red 5
   * Colacid Ponceau Special
   * Comacid Scarlet 2R
   * D&C Red No. 5
   * 4-((2,4-Dimethylphenyl)azo)-3-hydroxy-2,7-naphthalenedisulfonic acid,  
   disodium salt
   * 4-((2,4-Dimethylphenyl)azo)-3-hydroxy-2,7-naphthalenedisulphonic acid,  
   disodium salt
   * Disodium (2,4-dimethylphenylazo)-2-hydroxynaphthalene-3,6-disulfonate
   * Disodium (2,4-dimethylphenylazo)-2-hydroxynaphthalene-3,6-disulphonate
   * Disodium salt of 1-(2,4-xylylazo)-2-naphthol-3,6-disulfonic acid
   * Disodium salt of 1-(2,4-xylylazo)-2-naphthol-3,6-disulphonic acid
   * Edicol Ponceau RS
   * Edicol Supra Ponceau R
   * Fenazo Scarlet 2R
   * Food Red No. 101
   * Hexacol Ponceau MX
   * Hexacol Ponceau 2R
   * Hidacid Scarlet 2R
   * Hispacid Ponceau R
   * 3-Hydroxy-4-(2,4-xylylazo)-3,7-naphthalenedisulfonic acid, disodium salt
   * 3-Hydroxy-4-(2,4-xylylazo)-3,7-naphthalenedisulphonic acid, disodium salt
   * Java Ponceau 2R
   * Kiton Ponceau R
   * Kiton Ponceau 2R
   * Kiton Scarlet 2RC
   * Lake Ponceau
   * Lake Scarlet R
   * Lake Scarlet 2RBN
   * Naphthalene Lake Scarlet R
   * Naphthalene Scarlet R
   * Naphthazine Scarlet 2R
   * Neklacid Red RR
   * New Ponceau 4R
   * Paper Red HRR
   * Pas kwasowy 2 RL
   * Pigment Ponceau R
   * Ponceau BNA
   * Ponceau de xylidine
   * Ponceau FR
   * Ponceau G
   * Ponceau GR
   * Ponceau J
   * Ponceau MX
   * Ponceau NR
   * Ponceau PXM
   * Ponceau R
   * Ponceau 2R
   * Ponceau R (biological stain)
   * Ponceau 2R (biological stain)
   * Ponceau 2RE
   * Ponceau Red
   * Ponceau Red R
   * Ponceau 2R Extra A Export
   * Ponceau RG
   * Ponceau 2RL
   * Ponceau RS
   * Ponceau RR
   * Ponceau RR Type 8019
   * Ponceau 2RX
   * Ponceau xylidine (biological stain)
   * 1695 Red
   * Red For Lakes J
   * Red No. 503
   * Scarlet R
   * Scarlet 2R
   * Scarlet 2RB
   * Scarlet 2RL bluish
   * Scarlet RRA
   * Schultz No. 95
   * Tertracid Ponceau 2R
   * Xylidine Ponceau
   * Xylidine Ponceau 3RS
   * Xylidine Red
   * 1-Xylylazo-2-naphthol-3,6-disulfonic acid, disodium salt
   * 1-(2,4-Xylylazo)-2-naphthol-3,6-disulphonic acid, disodium salt
   * 1-Xylylazo-2-naphthol-3,6-disulphonic acid, disodium salt
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 23160 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - ataxia
REFERENCE :
   BCTKAG Bromatologia i Chemia Toksykologiczna.  (Ars Polona, POB 1001, 00-068
   Warsaw 1, Poland) V.4-    1971-  Volume(issue)/page/year: 21,65,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 4,375,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >6600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   SRTCAC Science Reports of the Research Institutes, Tohoku University, Series
   C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
   Cancer, 4-1 Seiryo-machi, Sendai, Japan)  V.1-   1949-
   Volume(issue)/page/year: 36(1-4),10,1989
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - antipsychotic
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 4,375,1966
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1530 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   SRTCAC Science Reports of the Research Institutes, Tohoku University, Series
   C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
   Cancer, 4-1 Seiryo-machi, Sendai, Japan)  V.1-   1949-
   Volume(issue)/page/year: 36(1-4),10,1989
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 45 gm/kg/90D-C
TOXIC EFFECTS :
   Liver - changes in liver weight
   Kidney, Ureter, Bladder - changes in bladder weight
   Endocrine - changes in spleen weight
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 4,375,1966
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 136 gm/kg/81W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 6,591,1968
 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 35 gm/kg/52W
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   10,653,1956
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volume(issue)/page/year: 49,1970,1982
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 300 umol/L
REFERENCE :
   SKEZAP Shokuhin Eiseigaku Zasshi.  Food Hygiene Journal.  (Nippon Shokuhin
   Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo
   150, Japan)  V.1-    1960-  Volume(issue)/page/year: 12,298,1971
 
TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 63 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 108,225,1983

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Sufficient Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 8,189,1975

   IARC Cancer Review:Human No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 8,189,1975

   IARC Cancer REIEW:Group 2B
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,56,1987

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M3143
       No. of Facilities: 212 (estimated)
       No. of Industries: 4
       No. of Occupations: 6
       No. of Employees: 2142 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M3143
       No. of Facilities: 131 (estimated)
       No. of Industries: 3
       No. of Occupations: 4
       No. of Employees: 1200 (estimated)
       No. of Female Employees: 874 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
   
   EPA GENETOX PROGRAM 1988, Negative: B subtilis rec assay
   
   EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; Histidine
   reversion-Ames test
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***