*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : QJ8600000
CHEMICAL NAME : 1-Naphthalenemethanamine,
N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-, (E)-
CAS REGISTRY NUMBER : 91161-71-6
BEILSTEIN REFERENCE NO. : 4256376
LAST UPDATED : 199709
DATA ITEMS CITED : 7
MOLECULAR FORMULA : C21-H25-N
MOLECULAR WEIGHT : 291.47
COMPOUND DESCRIPTOR : Drug
Human
SYNONYMS/TRADE NAMES :
* (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene methanamine
* Lamisil
* SF-86-327
* Terbinafine
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 210 mg/kg/6W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Taste) - change in function
REFERENCE :
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
Volume(issue)/page/year: 340,728,1992
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - man
DOSE/DURATION : 3918 ug/kg
TOXIC EFFECTS :
Gastrointestinal - other changes
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda
Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
Volume(issue)/page/year: 27,6087,1993
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - woman
DOSE/DURATION : 200 mg/kg/40D-I
TOXIC EFFECTS :
Behavioral - anorexia (human)
Liver - jaundice, cholestatic
Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
JOHEEC Journal of Hepathology. (Elsevier Science, 655 Avenue of the
Americas, New York, NY 10010) V.1- 1985- Volume(issue)/page/year:
24,753,1996
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
9,427,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 213 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
53XPA8 "Proceedings of the International Congress of Chemotherapy, 13th,
Vienna, 1983," Spitzy, K.H., and K. Karrer, eds., 18 vols., Vienna, Austria,
Verlag H. Egermann, 1983 Volume(issue)/page/year: 6,116/52,1983
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540,
08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year:
9,427,1984
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 393 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - ataxia
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
53XPA8 "Proceedings of the International Congress of Chemotherapy, 13th,
Vienna, 1983," Spitzy, K.H., and K. Karrer, eds., 18 vols., Vienna, Austria,
Verlag H. Egermann, 1983 Volume(issue)/page/year: 6,116/52,1983
*** END OF RECORD ***