*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QK2450000
CHEMICAL NAME           : 2-Naphthalenesulfonic acid,
                          6-hydroxy-5-((p-sulfophenyl)azo)-, disodium salt
CAS REGISTRY NUMBER     : 2783-94-0
LAST UPDATED            : 199707
DATA ITEMS CITED        : 19
MOLECULAR FORMULA       : C16-H10-N2-O7-S2.2Na
MOLECULAR WEIGHT        : 452.38
WISWESSER LINE NOTATION : L66J BNUNR DSWQ& CQ HSWQ &-NA- 2
COMPOUND DESCRIPTOR     : Tumorigen
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Acid Yellow TRA
   * A.F. Yellow No. 5
   * Aizen Food Yellow No. 5
   * Alabaster No. 3
   * Atul Sunset Yellow FCF
   * Canacert Sunset Yellow FCF
   * Certicol Sunset Yellow CFS
   * C.I. 15985
   * C.I. Food Yellow 3, disodium salt
   * Cilefa Orange S
   * Disodium salt of 1-p-sulphophenylazo-2-naphthol-6-sulphonic acid
   * Dolkwal Sunset Yellow
   * E 110
   * Edicol Supra Yellow FC
   * Eniacid Sunset Yellow
   * Eurocert Orange FCF
   * FD and C No. 6
   * FD and C Yellow 6
   * FD and C Yellow No. 6
   * Food Yellow 3
   * Food Yellow 6
   * Gelborange-S
   * HD Sunset Yellow FCF
   * HD Sunset Yellow FCF Supra
   * Hexacol Sunset Yellow FCF
   * Hexacol Sunset Yellow FCF Supra
   * 6-Hydroxy-5-((p-sulfophenyl)azo)-2-naphthalenesulfonic acid, disodium  
   salt
   * 6-Hydroxy-5-((4-sulfophenyl)azo)-2-naphthalenesulfonic acid, disodium  
   salt
   * 6-Hydroxy-5-((p-sulphophenyl)azo)-2-naphthalenesulphonic acid, disodium  
   salt
   * 6-Hydroxy-5-((4-sulphophenyl)azo)-2-naphthalenesulphonic acid, disodium  
   salt
   * KCA Foodcol Sunset Yellow FCF
   * L. Orange Z2010
   * Maple Sunset Yellow FCF
   * NCI-C53907
   * Orange PAL
   * Orange II R
   * Orange Yellow S
   * Orange Yellow S. AF
   * Orange Yellow S. FQ
   * Para Orange
   * Standacol Sunset Yellow FCF
   * 1-p-Sulfophenylazo-2-hydroxynaphthalene-6-sulfonate, disodium salt
   * 1-p-Sulfophenylazo-2-naphthol-6-sulfonic acid, disodium salt
   * 1-p-Sulphophenylazo-2-naphthol-6-sulphonic acid, disodium salt
   * Sun Orange A Geigy
   * Sunset Yellow
   * Sunset Yellow FCF
   * Sunset Yellow FCF Supra
   * Sunset Yellow FU
   * Sunset Yellow FU Supra
   * Sunset Yellow Lake
   * SUN Yellow
   * SUN Yellow A-CE
   * SUN Yellow A-FDC
   * SUN Yellow Extra Conc. A Export
   * SUN Yellow Extra Pure A
   * SUN Yellow FCF
   * Usacert Yellow No. 6
   * Usacert FD&C Yellow No. 6
   * 1351 Yellow
   * 1899 Yellow
   * Yellow No. 6
   * Yellow Orange S
   * Yellow Orange S Specially Pure
   * Yellow Orange Specially Pure 85
   * Yellow sun
   * Yellow SY for food
   * Zlut potravinarska 3
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >10 gm/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 5,747,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3800 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 5,747,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >6 gm/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 5,747,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4600 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 5,747,1967
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 243 gm/kg/96D-C
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Related to Chronic Data - changes in testicular weight
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 5,747,1967
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 476 mg/kg/28D-C
TOXIC EFFECTS :
   Blood - changes in leukocyte (WBC) count
REFERENCE :
   JPPMAB Journal of Pharmacy and Pharmacology.  (Pharmaceutical Soc. of Great
   Britain, 1 Lambeth High St., London SEI 7JN, UK)  V.1-    1949-
   Volume(issue)/page/year: 10,625,1958
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 1 gm/L
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   236,933,1987
 
TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 2 gm/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

                              *** REVIEWS ***
 
   IARC Cancer Review:Animal Inadequate Evidence
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 8,257,1975

   IARC Cancer Review:Human No Adequate Data
   IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
   to Man.  (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
   V.1-    1972-  Volume(issue)/page/year: 8,257,1975

   IARC Cancer Review:Group 3
   IMSUDL IARC Monographs, Supplement.  (WHO Publications Centre USA, 49
   Sheridan Ave., Albany, NY 12210)  No.1-    1979-  Volume(issue)/page/year:
   7,56,1987

   TOXICOLOGY REVIEW
   ARVPAX Annual Review of Pharmacology.  (Palo Alto, CA)  V.1-15, 1961-75. For
   publisher information, see ARPTDI.  Volume(issue)/page/year: 14,127,1974

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOHS - National Occupational Hazard Survey (1974)
     NOHS Hazard Code - M2135
       No. of Facilities: 2510 (estimated)
       No. of Industries: 14
       No. of Occupations: 21
       No. of Employees: 17624 (estimated)
   
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - M2135
       No. of Facilities: 11207 (estimated)
       No. of Industries: 67
       No. of Occupations: 62
       No. of Employees: 195835 (estimated)
       No. of Female Employees: 103566 (estimated)

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Histidine
   reversion-Ames test
   
   EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion
   
   EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; In vitro
   SCE-nonhuman
   
   EPA TSCA Section 8(b) CHEMICAL INVENTORY
   
   NCI Carcinogenesis Bioassay (feed);inadequate studies:mouse,rat
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-208,81

 
                            *** END OF RECORD ***