*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : QK2450000 CHEMICAL NAME : 2-Naphthalenesulfonic acid, 6-hydroxy-5-((p-sulfophenyl)azo)-, disodium salt CAS REGISTRY NUMBER : 2783-94-0 LAST UPDATED : 199707 DATA ITEMS CITED : 19 MOLECULAR FORMULA : C16-H10-N2-O7-S2.2Na MOLECULAR WEIGHT : 452.38 WISWESSER LINE NOTATION : L66J BNUNR DSWQ& CQ HSWQ &-NA- 2 COMPOUND DESCRIPTOR : Tumorigen Mutagen SYNONYMS/TRADE NAMES : * Acid Yellow TRA * A.F. Yellow No. 5 * Aizen Food Yellow No. 5 * Alabaster No. 3 * Atul Sunset Yellow FCF * Canacert Sunset Yellow FCF * Certicol Sunset Yellow CFS * C.I. 15985 * C.I. Food Yellow 3, disodium salt * Cilefa Orange S * Disodium salt of 1-p-sulphophenylazo-2-naphthol-6-sulphonic acid * Dolkwal Sunset Yellow * E 110 * Edicol Supra Yellow FC * Eniacid Sunset Yellow * Eurocert Orange FCF * FD and C No. 6 * FD and C Yellow 6 * FD and C Yellow No. 6 * Food Yellow 3 * Food Yellow 6 * Gelborange-S * HD Sunset Yellow FCF * HD Sunset Yellow FCF Supra * Hexacol Sunset Yellow FCF * Hexacol Sunset Yellow FCF Supra * 6-Hydroxy-5-((p-sulfophenyl)azo)-2-naphthalenesulfonic acid, disodium salt * 6-Hydroxy-5-((4-sulfophenyl)azo)-2-naphthalenesulfonic acid, disodium salt * 6-Hydroxy-5-((p-sulphophenyl)azo)-2-naphthalenesulphonic acid, disodium salt * 6-Hydroxy-5-((4-sulphophenyl)azo)-2-naphthalenesulphonic acid, disodium salt * KCA Foodcol Sunset Yellow FCF * L. Orange Z2010 * Maple Sunset Yellow FCF * NCI-C53907 * Orange PAL * Orange II R * Orange Yellow S * Orange Yellow S. AF * Orange Yellow S. FQ * Para Orange * Standacol Sunset Yellow FCF * 1-p-Sulfophenylazo-2-hydroxynaphthalene-6-sulfonate, disodium salt * 1-p-Sulfophenylazo-2-naphthol-6-sulfonic acid, disodium salt * 1-p-Sulphophenylazo-2-naphthol-6-sulphonic acid, disodium salt * Sun Orange A Geigy * Sunset Yellow * Sunset Yellow FCF * Sunset Yellow FCF Supra * Sunset Yellow FU * Sunset Yellow FU Supra * Sunset Yellow Lake * SUN Yellow * SUN Yellow A-CE * SUN Yellow A-FDC * SUN Yellow Extra Conc. A Export * SUN Yellow Extra Pure A * SUN Yellow FCF * Usacert Yellow No. 6 * Usacert FD&C Yellow No. 6 * 1351 Yellow * 1899 Yellow * Yellow No. 6 * Yellow Orange S * Yellow Orange S Specially Pure * Yellow Orange Specially Pure 85 * Yellow sun * Yellow SY for food * Zlut potravinarska 3 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : >10 gm/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 5,747,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3800 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - coma Gastrointestinal - hypermotility, diarrhea REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 5,747,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : >6 gm/kg TOXIC EFFECTS : Gastrointestinal - hypermotility, diarrhea REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 5,747,1967 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4600 mg/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - coma Gastrointestinal - hypermotility, diarrhea REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 5,747,1967 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 243 gm/kg/96D-C TOXIC EFFECTS : Gastrointestinal - other changes Related to Chronic Data - changes in testicular weight REFERENCE : FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 5,747,1967 TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 476 mg/kg/28D-C TOXIC EFFECTS : Blood - changes in leukocyte (WBC) count REFERENCE : JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 10,625,1958 ** MUTATION DATA ** TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Rodent - mouse Lymphocyte DOSE/DURATION : 1 gm/L REFERENCE : SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895- Volume(issue)/page/year: 236,933,1987 TYPE OF TEST : Cytogenetic analysis TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 2 gm/L REFERENCE : GMCRDC Gann Monograph on Cancer Research. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No. 11- 1971- Volume(issue)/page/year: 27,95,1981 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,257,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,257,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI. Volume(issue)/page/year: 14,127,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M2135 No. of Facilities: 2510 (estimated) No. of Industries: 14 No. of Occupations: 21 No. of Employees: 17624 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M2135 No. of Facilities: 11207 (estimated) No. of Industries: 67 No. of Occupations: 62 No. of Employees: 195835 (estimated) No. of Female Employees: 103566 (estimated) *** STATUS IN U.S. *** EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Histidine reversion-Ames test EPA GENETOX PROGRAM 1988, Negative: S cerevisiae gene conversion EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; In vitro SCE-nonhuman EPA TSCA Section 8(b) CHEMICAL INVENTORY NCI Carcinogenesis Bioassay (feed);inadequate studies:mouse,rat NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*. Volume(issue)/page/year: NCI-TR-208,81 *** END OF RECORD ***