*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QL6150000
CHEMICAL NAME           : 1H-Naphtho(2,1-b)pyran-1-one,
                          dodecahydro-5-(acetyloxy)-3-ethenyl-3,4a,7,7,10a-pent
                          amethyl- 6,10,10b-trihydroxy-,
                          (3R-(3-alpha,4a-beta,5-beta,6-beta,6a-alpha,10-alpha,
                          10a-beta,10b- alpha))-
CAS REGISTRY NUMBER     : 66575-29-9
OTHER CAS REGISTRY NOS. : 64657-11-0
LAST UPDATED            : 198910
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C22-H34-O7
MOLECULAR WEIGHT        : 410.56
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   *   7-beta-Acetoxy-8,13-epoxy-1-alpha,6-beta,9-alpha-trihydroxylabd-14-en-11
     -one
   * Coleonol
   * Colforsin
   * Forskolin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2550 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MRREDD Medicinal Research Reviews.  (John Wiley & Sons, Inc., 605 Third
   Ave., New York, NY 10158) V.1-    1981-  Volume(issue)/page/year: 3,201,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 92 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 31,1872,1988
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   MRREDD Medicinal Research Reviews.  (John Wiley & Sons, Inc., 605 Third
   Ave., New York, NY 10158) V.1-    1981-  Volume(issue)/page/year: 3,201,1983
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 68 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   JOETD7 Journal of Ethnopharmacology.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1979-  Volume(issue)/page/year:
   3,1,1981
 
                            *** END OF RECORD ***