*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QL8000200
CHEMICAL NAME           : 1,4-Naphthoquinone,
                          5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-,
                          (+)-
CAS REGISTRY NUMBER     : 517-89-5
BEILSTEIN REFERENCE NO. : 2058010
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C16-H16-O5
MOLECULAR WEIGHT        : 288.32
WISWESSER LINE NOTATION : L66 BV EVJ CYQ2UY1&1 GQ JQ
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * C.I. 75535
   * (+)-5,8-Dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone
   * 1,4-Naphthalenedione, 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-,  
   (R)-
   * Shikonin
   * (+)-Shikonin
   * Tokyo Violet
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   73,193,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   73,193,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 16 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PJPHEO Pakistan Journal of Pharmacology.  (c/o Univ. of Karachi, Faculty of
   Pharmacy, Karachi, 32, Pakistan)  V.1-    1984-  Volume(issue)/page/year:
   3(1-2),43,1986
 
                            *** END OF RECORD ***