*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QL8485000
CHEMICAL NAME           : 1,4-Naphthoquinone, 2-hydroxy-3-methyl-
CAS REGISTRY NUMBER     : 483-55-6
BEILSTEIN REFERENCE NO. : 1868473
REFERENCE               : 4-08-00-02375 (Beilstein Handbook Reference)
LAST UPDATED            : 199709
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C11-H8-O3
MOLECULAR WEIGHT        : 188.19
WISWESSER LINE NOTATION : L66 BV EVJ CQ D1
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * 2-Hydroxy-3-methyl-1,4-naphthoquinone
   * 3-Hydroxy-2-methyl-1,4-naphthoquinone
   * 2-Methyl-3-hydroxy-1,4-naphthoquinone
   * 1,4-Naphthalenedione, 2-hydroxy-3-methyl-
   * Phthiocol
   * Phthiokol
   * Q 1212
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 43,125,1940
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 43,125,1940
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 43,125,1940
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3 gm/kg/30D-I
TOXIC EFFECTS :
   Blood - pigmented or nucleated red blood cells
   Blood - changes in erythrocyte (RBC) count
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 43,125,1940
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 4 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 93,447,1982
 
                            *** END OF RECORD ***