*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QL8750000
CHEMICAL NAME           : 1,4-Naphthoquinone, 2-hydroxy-3-(3-methyl-2-butenyl)-
CAS REGISTRY NUMBER     : 84-79-7
BEILSTEIN REFERENCE NO. : 2051889
REFERENCE               : 4-08-00-02487 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C15-H14-O3
MOLECULAR WEIGHT        : 242.29
WISWESSER LINE NOTATION : L66 BV EVJ CQ D2UY1&1
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Bethabarra wood
   * C.I. 75490
   * C.I. Natural Yellow 16
   * Greenharten
   * 2-Hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione
   * 2-Hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone
   * IPE-tobacco wood
   * Lapachol
   * Lapachic acid
   * Lapachol wood
   * NSC-11905
   * Surinam greenheart wood
   * Taigu wood
   * Taiguic acid
   * Tecomin
   * Zlut prirodni 16
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   17,1,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 487 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   17,1,1970
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 26,570,1983
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 24 gm/kg/4W-I
TOXIC EFFECTS :
   Blood - normocytic anemia
   Blood - changes in other cell count (unspecified)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   17,1,1970
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : 12 gm/kg/4W-I
TOXIC EFFECTS :
   Related to Chronic Data - death
REFERENCE :
   FEPRA7 Federation Proceedings, Federation of American Societies for
   Experimental Biology. (Bethesda, MD)  V.1-46, 1942-87.
   Volume(issue)/page/year: 26,539,1967
 
                            *** END OF RECORD ***