*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : QN2791655 CHEMICAL NAME : 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-(3-(1-amino-1-methylethyl)- 1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-4-oxo-, hydrochloride (5:6), (R)- CAS REGISTRY NUMBER : 153566-55-3 LAST UPDATED : 199606 DATA ITEMS CITED : 1 MOLECULAR FORMULA : C19-H23-F-N4-O3.6/5Cl-H COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * PD 138312 hydrochloride *** HEALTH HAZARD DATA *** ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 1400 mg/kg/2W-I TOXIC EFFECTS : Cardiac - EKG changes not diagnostic of specified effects Gastrointestinal - nausea or vomiting Nutritional and Gross Metabolic - weight loss or decreased weight gain REFERENCE : TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 30,338,1996 *** END OF RECORD ***