*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QN2791655
CHEMICAL NAME           : 1,8-Naphthyridine-3-carboxylic acid,
                          1,4-dihydro-7-(3-(1-amino-1-methylethyl)-
                          1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-4-oxo-,
                          hydrochloride (5:6), (R)-
CAS REGISTRY NUMBER     : 153566-55-3
LAST UPDATED            : 199606
DATA ITEMS CITED        : 1
MOLECULAR FORMULA       : C19-H23-F-N4-O3.6/5Cl-H
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * PD 138312 hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 1400 mg/kg/2W-I
TOXIC EFFECTS :
   Cardiac - EKG changes not diagnostic of specified effects
   Gastrointestinal - nausea or vomiting
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 30,338,1996
 
                            *** END OF RECORD ***