*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QO6790000
CHEMICAL NAME           : Neocarzinostatin, bis(succinyl) derivative
CAS REGISTRY NUMBER     : 58858-29-0
LAST UPDATED            : 198708
DATA ITEMS CITED        : 2
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Bis-N-succinyl neocarzinostatin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 960 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - alteration in gastric secretion
   Blood - changes in spleen
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 31,468,1978
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 1 mg/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 31,468,1978
 
                            *** END OF RECORD ***