*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QP7050000
CHEMICAL NAME           : Neostam
CAS REGISTRY NUMBER     : 1344-34-9
LAST UPDATED            : 199712
DATA ITEMS CITED        : 28
MOLECULAR FORMULA       : C36-H49-N3-O22-Sb3.Na
MOLECULAR WEIGHT        : 1264.12
WISWESSER LINE NOTATION : T6OTJ CQ DQ EQ F1Q BMR D-SB-WO-SB-O&R DM- BT6OTJ CQ
                          DQ EQ F1Q&O-SB-QO&R DM- BT6OTJ CQ DQ EQ F
COMPOUND DESCRIPTOR     : Drug
                          Organometallic
SYNONYMS/TRADE NAMES :
   * Glucostibamine sodium
   * Glucostimidine sodium
   * Nitrogen glucoside of sodium p-aminophenylstibonate
   * Neostam stibamine glucoside
   * Sodium p-aminobenzenestibonate glucoside
   * Sodium stibanilate glucoside
   * Stibamine glucoside
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1475 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 81,224,1944
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 91 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 87,119,1946

                              *** REVIEWS ***
 
   ACGIH TLV-TWA 0.5 mg(Sb)/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year:
   TLV/BEI,1997

                    *** U.S. STANDARDS AND REGULATIONS ***
 
   MSHA STANDARD-air:TWA 0.5 mg(Sb)/m3
   DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
   (BEIs) booklet issues by American Conference of Governmental Industrial
   Hygienists (ACGIH), Cincinnati, OH, 1996  Volume(issue)/page/year: 3,15,1971

   OSHA PEL (Gen Indu):8H TWA 0.5 mg(Sb)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1910.1000,1994

   OSHA PEL (Construc):8H TWA 0.5 mg(Sb)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1926.55,1994

   OSHA PEL (Shipyard):8H TWA 0.5 mg(Sb)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   29,1915.1000,1993

   OSHA PEL (Fed Cont):8H TWA 0.5 mg(Sb)/m3
   CFRGBR Code of Federal Regulations.  (U.S. Government Printing Office, Supt.
   of Documents, Washington, DC 20402)  Volume(issue)/page/year:
   41,50-204.50,1994

                    *** OCCUPATIONAL EXPOSURE LIMITS ***
 
   OEL-ARAB Republic of Egypt:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-AUSTRALIA:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-AUSTRIA:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-BELGIUM:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-DENMARK:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-FINLAND:.TWA  (0.5 mg(Sb)/m3) JAN 1993
   
   OEL-FRANCE:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-GERMANY:TWA 0.5 mg(Sb)/m3 (total dust) JAN 1993
   
   OEL-HUNGARY:STEL 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-THE NETHERLANDS:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-THE PHILIPPINES:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-POLAND:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-RUSSIA:TWA 0.2 mg(Sb)/m3;STEL 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-SWEDEN:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-SWITZERLAND:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-TURKEY:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL-UNITED KINGDOM:TWA 0.5 mg(Sb)/m3 JAN 1993
   
   OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
   
   OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
   NIOSH REL TO ANTIMONY-air:10H TWA 0.5 mg(Sb)/m3
REFERENCE :
   NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
   Health, Education, and Welfare, Reports and Memoranda.
   Volume(issue)/page/year: DHHS #92-100,1992

 
                            *** END OF RECORD ***