*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QQ0865000
CHEMICAL NAME           : Nerium oleander L., extract
CAS REGISTRY NUMBER     : 84929-39-5
LAST UPDATED            : 199706
DATA ITEMS CITED        : 5
COMPOUND DESCRIPTOR     : Natural Product
SYNONYMS/TRADE NAMES :
   * Ceylon rose leaves
   * Extract of Oleander Leaves
   * Nerium oleander leaf extract
   * Oleander extract
   * Oleander, Nerium oleander, ext.
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 30 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 1,939,1976
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2857 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 1,939,1976
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Cardiac - pulse rate
   Gastrointestinal - changes in structure or function of salivary glands
   Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 189,12,1971
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - chicken
DOSE/DURATION           : 18750 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - ataxia
   Gastrointestinal - nausea or vomiting
REFERENCE :
   VBBHAS Veterinary Bulletin (London).  (CAB International, Central Sales,
   Farnham House, Farnham Royal, Slough SL2 3BN, UK)  V.1-   1931-
   Volume(issue)/page/year: 10,624,1940
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Bird - duck
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - ataxia
   Gastrointestinal - nausea or vomiting
REFERENCE :
   VBBHAS Veterinary Bulletin (London).  (CAB International, Central Sales,
   Farnham House, Farnham Royal, Slough SL2 3BN, UK)  V.1-   1931-
   Volume(issue)/page/year: 10,624,1940
 
                            *** END OF RECORD ***