*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : QQ0865000 CHEMICAL NAME : Nerium oleander L., extract CAS REGISTRY NUMBER : 84929-39-5 LAST UPDATED : 199706 DATA ITEMS CITED : 5 COMPOUND DESCRIPTOR : Natural Product SYNONYMS/TRADE NAMES : * Ceylon rose leaves * Extract of Oleander Leaves * Nerium oleander leaf extract * Oleander extract * Oleander, Nerium oleander, ext. *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 30 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 1,939,1976 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2857 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 1,939,1976 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Mammal - dog DOSE/DURATION : 25 mg/kg TOXIC EFFECTS : Cardiac - pulse rate Gastrointestinal - changes in structure or function of salivary glands Kidney, Ureter, Bladder - urine volume increased REFERENCE : AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 189,12,1971 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - chicken DOSE/DURATION : 18750 mg/kg TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - ataxia Gastrointestinal - nausea or vomiting REFERENCE : VBBHAS Veterinary Bulletin (London). (CAB International, Central Sales, Farnham House, Farnham Royal, Slough SL2 3BN, UK) V.1- 1931- Volume(issue)/page/year: 10,624,1940 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Bird - duck DOSE/DURATION : 1200 mg/kg TOXIC EFFECTS : Behavioral - muscle weakness Behavioral - ataxia Gastrointestinal - nausea or vomiting REFERENCE : VBBHAS Veterinary Bulletin (London). (CAB International, Central Sales, Farnham House, Farnham Royal, Slough SL2 3BN, UK) V.1- 1931- Volume(issue)/page/year: 10,624,1940 *** END OF RECORD ***