*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : QR6500000
CHEMICAL NAME : Nickel, compd with pi-cyclopentadienyl (1:2)
CAS REGISTRY NUMBER : 1271-28-9
LAST UPDATED : 199701
DATA ITEMS CITED : 19
MOLECULAR FORMULA : C10-H10-Ni
MOLECULAR WEIGHT : 188.91
WISWESSER LINE NOTATION : L50J 0-NI- 0L50J
COMPOUND DESCRIPTOR : Tumorigen
SYNONYMS/TRADE NAMES :
* pi-Cyclopentadienyl compd. with nickel
* Di-pi-cyclopentadienylnickel
* Nickel biscyclopentadiene
* Nickelocene
* Nikelocen
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 490 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PWPSA8 Proceedings of the Western Pharmacology Society. (Univ. of
California Dept. of Pharmacology, Los Angeles, CA 90024) V.1- 1958-
Volume(issue)/page/year: 11,39,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
National Cancer Institute by The Institute of Chemical Biology, University
of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year:
PH43-64-886
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 82 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
National Cancer Institute by The Institute of Chemical Biology, University
of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year:
PH43-64-886
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 600 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Lungs, Thorax, or Respiration - dyspnea
Gastrointestinal - hypermotility, diarrhea
REFERENCE :
PWPSA8 Proceedings of the Western Pharmacology Society. (Univ. of
California Dept. of Pharmacology, Los Angeles, CA 90024) V.1- 1958-
Volume(issue)/page/year: 11,39,1968
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 86 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PWPSA8 Proceedings of the Western Pharmacology Society. (Univ. of
California Dept. of Pharmacology, Los Angeles, CA 90024) V.1- 1958-
Volume(issue)/page/year: 11,39,1968
** TUMORIGENIC DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 600 mg/kg/52W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
National Cancer Institute by The Institute of Chemical Biology, University
of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year:
PH43-64-886
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Musculoskeletal - tumors
Tumorigenic - tumors at site of application
REFERENCE :
PWPSA8 Proceedings of the Western Pharmacology Society. (Univ. of
California Dept. of Pharmacology, Los Angeles, CA 90024) V.1- 1958-
Volume(issue)/page/year: 14,68,1971
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 600 mg/kg/47W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Blood - lymphoma, including Hodgkin's disease
Tumorigenic - tumors at site of application
REFERENCE :
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
National Cancer Institute by The Institute of Chemical Biology, University
of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year:
PH43-64-886
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 650 mg/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Musculoskeletal - tumors
Tumorigenic - tumors at site of application
REFERENCE :
PWPSA8 Proceedings of the Western Pharmacology Society. (Univ. of
California Dept. of Pharmacology, Los Angeles, CA 90024) V.1- 1958-
Volume(issue)/page/year: 14,68,1971
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1260 mg/kg/56W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
National Cancer Institute by The Institute of Chemical Biology, University
of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year:
PH43-64-886
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Musculoskeletal - tumors
Skin and Appendages - tumors
REFERENCE :
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
National Cancer Institute by The Institute of Chemical Biology, University
of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year:
PH43-64-886
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 50 mg/kg/46W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
NCIUS* Progress Report for Contract No. PH-43-64-886, Submitted to the
National Cancer Institute by The Institute of Chemical Biology, University
of San Francisco. (San Francisco, CA 94117) Volume(issue)/page/year:
PH43-64-886
*** REVIEWS ***
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 11,75,1976
IARC Cancer Review:Animal Limited Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 49,257,1990
TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: Ni,168,1975
TOXICOLOGY REVIEW
ACLSCP Annals of Clinical and Laboratory Science. (1833 Delancey Pl.,
Philadelphia, PA 19103) V.1- 1971- Volume(issue)/page/year: 3,156,1973
TOXICOLOGY REVIEW
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach
CH-4009 Basel, Switzerland) V.1- 1960- Volume(issue)/page/year:
12,102,1969
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen
*** END OF RECORD ***