*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : QR9800000
CHEMICAL NAME : Nickel sulfide (3:2)
CAS REGISTRY NUMBER : 12035-72-2
LAST UPDATED : 199712
DATA ITEMS CITED : 93
MOLECULAR FORMULA : Ni3-S2
MOLECULAR WEIGHT : 240.25
WISWESSER LINE NOTATION : NI3 S2
COMPOUND DESCRIPTOR : Tumorigen
Mutagen
Reproductive Effector
SYNONYMS/TRADE NAMES :
* Nickel sesquisulfide
* Nickel subsulfide
* Nickel subsulphide
* alpha-Nickel sulfide (3:2) crystalline
* Nickel sulphide
* Nickel tritadisulphide
* Trinickel disulphide
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
SchF## Personal Communication from F.W. Schaller, Inco Ltd., Park 80 West
Plaza Two, Saddle Brook, NJ 07662, May 16, 1986 Volume(issue)/page/year:
16MAY1986
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intratracheal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 4 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 40,313,1986
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 102 ug/kg
TOXIC EFFECTS :
Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
(usually neuromuscular blockage)
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JOHYAY Journal of Hygiene. (Cambridge Univ. Press, 32 E. 57th St., New
York, NY 10022) V.1- 1901- Volume(issue)/page/year: 8,565,1908
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 14732 ug/m3/6H/12D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - changes in lung weight
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 50,145,1988
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1800 ug/m3/6H/13W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
12,584,1989
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 29872 ug/m3/6H/12D-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - changes in lung weight
Related to Chronic Data - death
REFERENCE :
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
Limerick, Ireland) V.1- 1973- Volume(issue)/page/year: 50,145,1988
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1800 ug/m3/6H/13W-I
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Lungs, Thorax, or Respiration - other changes
Lungs, Thorax, or Respiration - changes in lung weight
REFERENCE :
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year:
12,584,1989
** TUMORIGENIC DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 mg/m3/6H/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Endocrine - tumors
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-453,1996
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 970 ug/m3/6H/76W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
54,1165,1975
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB
211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
Volume(issue)/page/year: 79,212,1988
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intravenous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Eye) - tumors
Tumorigenic - tumors at site of application
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 39,330,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 115 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Musculoskeletal - tumors
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 4,275,1983
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intrapleural
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 40 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
55DXAE "Progress in Nickel Toxicology, Proceedings of the International
Conference on Nickel Metabolism and Toxicology, 3rd, 1984," Brown, S.S., and
F.W. Sunderman, Jr., eds., Oxford, UK, Blackwell Scientific Pub. Ltd., 1985
Volume(issue)/page/year: -,37,1985
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Ocular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2500 ug/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Eye) - tumors
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: DOE/EV/03140-5
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Parenteral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 40 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
38,268,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 40 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
ACLSCP Annals of Clinical and Laboratory Science. (1833 Delancey Pl.,
Philadelphia, PA 19103) V.1- 1971- Volume(issue)/page/year: 18,353,1988
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intratesticular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 18,52,1977
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intrarenal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 25 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
LAINAW Laboratory Investigation. (Williams & Wilkins Co., 428 E. Preston
St., Baltimore, MD 21202) V.1- 1952- Volume(issue)/page/year: 35,71,1976
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 200 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Tumorigenic - tumors at site of application
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
22,158,1962
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Implant
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 27 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Musculoskeletal - tumors
Tumorigenic - tumors at site of application
REFERENCE :
EJCBDN European Journal of Cell Biology. (Wissenschaftliche
Verlagsgesellschaft, Postfach 40, D-7000, Stuttgart l, Fed. Rep. Ger.) V.19-
1979- Volume(issue)/page/year: 19,276,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 80 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Musculoskeletal - tumors
Tumorigenic - tumors at site of application
REFERENCE :
AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.1- 1967- Volume(issue)/page/year:
91,57,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Multiple routes
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 272 gm/kg/18W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Skin and Appendages - tumors
Tumorigenic - tumors at site of application
REFERENCE :
AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.1- 1967- Volume(issue)/page/year:
91,57,1978
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 229 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Musculoskeletal - tumors
Tumorigenic - tumors at site of application
REFERENCE :
IAPUDO IARC Publications. (WHO Publications Centre USA, 49 Sheridan Ave.,
Albany, NY 12210) No.27- 1979- Volume(issue)/page/year: 53,127,1984
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Ocular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Sense Organs and Special Senses (Eye) - tumors
REFERENCE :
IOVSDA Investigative Ophthalmology and Visual Science. (Lippincott/Harper,
Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.16-
1977- Volume(issue)/page/year: 22,768,1982
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 10 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Tumorigenic - tumors at site of application
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 4,461,1983
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 970 ug/m3/6H/76W-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60,
1940-78. For publisher information, see JJIND8. Volume(issue)/page/year:
54,1165,1975
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 40 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Musculoskeletal - tumors
Tumorigenic - tumors at site of application
REFERENCE :
AEMBAP Advances in Experimental Medicine and Biology. (Plenum Pub. Corp.,
233 Spring St., New York, NY 10013) V.1- 1967- Volume(issue)/page/year:
91,57,1978
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intrarenal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 23 mg/kg
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 2(6),1511,1979
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intrarenal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 45 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Kidney, Ureter, Bladder - Kidney tumors
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest
South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
Volume(issue)/page/year: 2(6),1511,1979
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 100 mg/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Tumorigenic - tumors at site of application
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 8,1005,1987
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intratesticular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 40 mg/kg
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria
Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly
Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
Volume(issue)/page/year: 18,52,1977
TYPE OF TEST : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4800 ug/kg
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria
Lungs, Thorax, or Respiration - tumors
Tumorigenic - tumors at site of application
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 4,461,1983
** REPRODUCTIVE DATA **
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rat
DOSE : 80 mg/kg
SEX/DURATION : female 6 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
43,381,1978
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Intrarenal
SPECIES OBSERVED : Rodent - rat
DOSE : 50 mg/kg
SEX/DURATION : female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
50WKA3 "Reproduction and Developmental Toxicity of Metals, Proceedings of a
Joint Meeting, Rochester, 1982," Clarkson, T.W., et al., eds., New York,
Plenum Pub. Corp., 1983 Volume(issue)/page/year: -,399,1983
** MUTATION DATA **
TYPE OF TEST : Dominant lethal test
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 5 mg/L
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For
publisher information, see EMMUEG. Volume(issue)/page/year: 8,621,1986
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Human Fibroblast
DOSE/DURATION : 10 umol/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
47,3815,1987
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 1 mg/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
41,4136,1981
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 1 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 300,179,1993
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - rat Liver
DOSE/DURATION : 3 mmol/L
REFERENCE :
SinJF# Personal Communication from J.F. Sina, Merck Institute for
Therapeutic Research, West Point, PA 19486, Oct. 26, 1982
Volume(issue)/page/year: 26OCT1982
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - mouse Embryo
DOSE/DURATION : 1 ug/L
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year:
41,4136,1981
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Kidney
DOSE/DURATION : 10 mg/L
REFERENCE :
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science
Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
Volume(issue)/page/year: 12,185,1986
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 5 umol/plate
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 1,132,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 10 mg/L
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 3,657,1982
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Rodent - hamster Embryo
DOSE/DURATION : 10 mg/L
REFERENCE :
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1975- Volume(issue)/page/year:
17,273,1983
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Ovary
DOSE/DURATION : 5 mg/L
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
84,278,1986
TYPE OF TEST : DNA adduct
TEST SYSTEM : Mammal - species unspecified Lymphocyte
DOSE/DURATION : 4800 mg/L
REFERENCE :
BICHAW Biochemistry. (American Chemical Soc., Distribution Office Dept.
223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1962-
Volume(issue)/page/year: 21,771,1982
*** REVIEWS ***
ACGIH TLV-TWA 1 mg(Ni)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 11,75,1976
IARC Cancer Review:Animal Sufficient Evidence
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals
to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210)
V.1- 1972- Volume(issue)/page/year: 49,257,1990
TOXICOLOGY REVIEW
ACLSCP Annals of Clinical and Laboratory Science. (1833 Delancey Pl.,
Philadelphia, PA 19103) V.1- 1971- Volume(issue)/page/year: 3,156,1973
TOXICOLOGY REVIEW
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For
publisher information, see FCTOD7. Volume(issue)/page/year: 9,105,1971
TOXICOLOGY REVIEW
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series,"
Washington, DC, National Academy of Sciences, 1972-77
Volume(issue)/page/year: Ni,168,1975
TOXICOLOGY REVIEW
PEXTAR Progress in Experimental Tumor Research. (S. Karger AG, Postfach
CH-4009 Basel, Switzerland) V.1- 1960- Volume(issue)/page/year:
12,102,1969
TOXICOLOGY REVIEW
DICHAK Diseases of the Chest. (Chicago, IL) V.1-56, 1935-69. For
publisher information, see CHETBF. Volume(issue)/page/year: 54,527,1968
TOXICOLOGY REVIEW
PAPOAC Patologia Polska. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland)
V.1- 1950- Volume(issue)/page/year: 23,135,1972
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD-air:TWA 1 mg(Ni)/m3
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,178,1971
OSHA PEL (Gen Indu):8H TWA 1 mg(Ni)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):8H TWA 1 mg(Ni)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):8H TWA 1 mg(Ni)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):8H TWA 1 mg(Ni)/m3
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 0.1 mg(Ni)/m3 JAN 1993
OEL-AUSTRALIA:TWA 1 mg(Ni)/m3 JAN 1993
OEL-BELGIUM:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993
OEL-DENMARK:TWA 0.05 mg(Ni)/m3;Carcinogen JAN 1993
OEL-DENMARK:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993
OEL-FINLAND:TWA 0.1 mg(Ni)/m3;Carcinogen JAN 1993
OEL-FINLAND:TWA 0.1 mg(Ni)/m3;Skin;Carcinogen (insoluble compounds) JAN 1993
OEL-FINLAND;Carcinogen JAN 1993
OEL-FRANCE:TWA 1 mg(Ni)/m3 JAN 1993
OEL-GERMANY;Carcinogen JAN 1993
OEL-HUNGARY:STEL 0.005 mg(Ni)/m3;Carcinogen (insoluble compounds) JAN 1993
OEL-JAPAN:TWA 1 mg(Ni)/m3;Carcinogen JAN 1993
OEL-THE NETHERLANDS:TWA 0.1 mg(Ni)/m3 JAN 1993
OEL-THE NETHERLANDS:TWA 1 mg(Ni)/m3 (insoluble compounds) JAN 1993
OEL-THE PHILIPPINES:TWA 1 mg(Ni)/m3 JAN 1993
OEL-RUSSIA:STEL 0.05 mg(Ni)/m3 JAN 1993
OEL-SWEDEN:TWA 0.01 mg/m3;Carcinogen JAN 1993
OEL-SWEDEN:TWA 0.5 mg(Ni)/m3 JAN 1993
OEL-SWITZERLAND:TWA 0.5 mg(Ni)/m3 (insoluble compounds) JAN 1993
OEL-SWITZERLAND:TWA 0.5 mg(Ni)/m3;Carcinogen JAN 1993
OEL-THAILAND:TWA 1 mg(Ni)/m3 JAN 1993
OEL-UNITED KINGDOM:TWA 0.5 mg(Ni)/m3 (insoluble compounds) JAN 1993
OEL-UNITED KINGDOM:TWA 1 mg(Ni)/m3 JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO NICKEL, INORGANIC-air:10H CA TWA 0.015 mg(Ni)/m3
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NTP Carcinogenesis studies (inhalation);clear evidence:rat
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-453,96
NTP Carcinogenesis studies (inhalation);no evidence:mouse
NTPTR* National Toxicology Program Technical Report Series. (Research
Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-453,96
NTP 7th Annual Report on Carcinogens, 1992 : anticipated to be carcinogen
*** END OF RECORD ***