*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QS4005000
CHEMICAL NAME           : Nicotinamide, N-antipyrinyl-
CAS REGISTRY NUMBER     : 2139-47-1
BEILSTEIN REFERENCE NO. : 0307504
REFERENCE               : 5-25-14-00153 (Beilstein Handbook Reference)
LAST UPDATED            : 199612
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C17-H16-N4-O2
MOLECULAR WEIGHT        : 308.37
WISWESSER LINE NOTATION : T6NJ CVM- DT5NNVJ A1 BR& E1
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * N-Antipyrinylnicotinamide
   *   N-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-pyridineca
     rboxamide
   * Niapyrin
   * Nicazane
   * Nicodon
   * Nicodone
   * Nicofesone
   * Nicophesone
   * Nicophezon
   * Nicotinamide, N-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)-
   * Nicotinic acid, amidophenyldimethylpyrazolone
   * 4-Nicotinoylamido-1-phenyl-2,3-dimethyl-5-pyrazolone
   * Nicopyron
   * Nicoreumal
   * Nicoron
   * Nicotazone
   * 4-(Nicotinamido)antipyrine
   * Nicotinic acid 4-antipyrilamide
   * Nicotinoylaminoantipyrine
   * 4-(Nicotinoylamino)antipyrine
   * Anicotinoylantipyrine
   * Nicotinsaeureamidophenyldimethylpyrazolons
   * Nicozone
   * Nifenazon
   * Nifenazone
   * Nikodon
   * Nikofezon
   * Phenicazone
   * Thylin
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7890 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - convulsions or effect on seizure threshold
   Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 12,235,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1280 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 9,132,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3750 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IJPAAO Indian Journal of Pharmacy.  (Bombay, India)  V.1-40(1), 1939-78. For
   publisher information, see IJSIDW.  Volume(issue)/page/year: 26,99,1964
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JDGRAX Journal of Drug Research.  (National Organization for Drug Research
   and Control, POB 29, Cairo, Egypt)  V.2-    1969-  Volume(issue)/page/year:
   4,89,1972
 
                            *** END OF RECORD ***