*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : QS4005000 CHEMICAL NAME : Nicotinamide, N-antipyrinyl- CAS REGISTRY NUMBER : 2139-47-1 BEILSTEIN REFERENCE NO. : 0307504 REFERENCE : 5-25-14-00153 (Beilstein Handbook Reference) LAST UPDATED : 199612 DATA ITEMS CITED : 4 MOLECULAR FORMULA : C17-H16-N4-O2 MOLECULAR WEIGHT : 308.37 WISWESSER LINE NOTATION : T6NJ CVM- DT5NNVJ A1 BR& E1 COMPOUND DESCRIPTOR : Drug SYNONYMS/TRADE NAMES : * N-Antipyrinylnicotinamide * N-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-3-pyridineca rboxamide * Niapyrin * Nicazane * Nicodon * Nicodone * Nicofesone * Nicophesone * Nicophezon * Nicotinamide, N-(2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl)- * Nicotinic acid, amidophenyldimethylpyrazolone * 4-Nicotinoylamido-1-phenyl-2,3-dimethyl-5-pyrazolone * Nicopyron * Nicoreumal * Nicoron * Nicotazone * 4-(Nicotinamido)antipyrine * Nicotinic acid 4-antipyrilamide * Nicotinoylaminoantipyrine * 4-(Nicotinoylamino)antipyrine * Anicotinoylantipyrine * Nicotinsaeureamidophenyldimethylpyrazolons * Nicozone * Nifenazon * Nifenazone * Nikodon * Nikofezon * Phenicazone * Thylin *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 7890 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands REFERENCE : KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 12,235,1978 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1280 mg/kg TOXIC EFFECTS : Behavioral - tremor Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,132,1959 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 3750 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IJPAAO Indian Journal of Pharmacy. (Bombay, India) V.1-40(1), 1939-78. For publisher information, see IJSIDW. Volume(issue)/page/year: 26,99,1964 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 4200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969- Volume(issue)/page/year: 4,89,1972 *** END OF RECORD ***