*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QT1750000
CHEMICAL NAME           : Nicotinic acid, hydrazide
CAS REGISTRY NUMBER     : 553-53-7
LAST UPDATED            : 199709
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C6-H7-N3-O
MOLECULAR WEIGHT        : 137.16
WISWESSER LINE NOTATION : T6NJ CVMZ
COMPOUND DESCRIPTOR     : Tumorigen
SYNONYMS/TRADE NAMES :
   * Hydrazine, nicotinoyl-
   * Niazid
   * Nicotinic hydrazide
   * Nicotinoyl hydrazine
   * Nicotinylhydrazide
   * 3-Pyridinecarboxylic acid, hydrazide
   * 3-Pyridoyl hydrazine
   * (3-Pyridylcarbonyl)hydrazine
   * WS 102
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#04178
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CBCCT* "Summary Tables of Biological Tests," National Research Council
   Chemical-Biological Coordination Center.  (National Academy of Science
   Library, 2101 Constitution Ave., NW, Washington, DC 20418)
   Volume(issue)/page/year: 7,691,1955
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 124 gm/kg/71W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   ONCOBS Oncology.  (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 
     1967-  Volume(issue)/page/year: 38,106,1981
 
                            *** END OF RECORD ***