*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QT2030000
CHEMICAL NAME           : Nicotinic acid, 3-pyridylmethyl ester, fumarate
CAS REGISTRY NUMBER     : 63861-52-9
LAST UPDATED            : 198910
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C12-H10-N2-O2.C4-H4-O4
MOLECULAR WEIGHT        : 330.32
WISWESSER LINE NOTATION : T6NJ CVO1- CT6NJ &QV1U1VQ -T
COMPOUND DESCRIPTOR     : Drug
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Hoku-218
   * 3-Pyridylmethyl nicotinate monofumarate
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 4875 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   AMBNAS Acta Medica et Biologica (Niigata).  (Niigata Univ. School of
   Medicine, 1 Asahi-machi-dori, Niigata 951, Japan)  V.1-    1953-
   Volume(issue)/page/year: 26,117,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 9750 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   AMBNAS Acta Medica et Biologica (Niigata).  (Niigata Univ. School of
   Medicine, 1 Asahi-machi-dori, Niigata 951, Japan)  V.1-    1953-
   Volume(issue)/page/year: 26,117,1978
 
                            *** END OF RECORD ***