*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : QU3340000
CHEMICAL NAME           : Nisin
CAS REGISTRY NUMBER     : 1414-45-5
LAST UPDATED            : 199512
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C143-H230-N42-O37-S7
MOLECULAR WEIGHT        : 3354.57
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * NSC-112903
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 4(2),228,1980
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2250 ug/kg
TOXIC EFFECTS :
   Brain and Coverings - meningeal changes
   Brain and Coverings - changes in cerebral spinal fluid
   Behavioral - irritability
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 7,438,1952
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 290 mg/kg/18D-I
TOXIC EFFECTS :
   Vascular - thrombosis distant from injection site
REFERENCE :
   BJPCAL British Journal of Pharmacology and Chemotherapy.  (London, UK)
   V.1-33, 1946-68.  For publisher information, see BJPCBM.
   Volume(issue)/page/year: 7,438,1952
 
                            *** END OF RECORD ***