*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : QU3340000 CHEMICAL NAME : Nisin CAS REGISTRY NUMBER : 1414-45-5 LAST UPDATED : 199512 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C143-H230-N42-O37-S7 MOLECULAR WEIGHT : 3354.57 COMPOUND DESCRIPTOR : Drug Natural Product SYNONYMS/TRADE NAMES : * NSC-112903 *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 100 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 4(2),228,1980 TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Parenteral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 2250 ug/kg TOXIC EFFECTS : Brain and Coverings - meningeal changes Brain and Coverings - changes in cerebral spinal fluid Behavioral - irritability REFERENCE : BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 7,438,1952 ** OTHER MULTIPLE DOSE TOXICITY DATA ** TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 290 mg/kg/18D-I TOXIC EFFECTS : Vascular - thrombosis distant from injection site REFERENCE : BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 7,438,1952 *** END OF RECORD ***