*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : QW9800000
CHEMICAL NAME : Nitrogen dioxide
CAS REGISTRY NUMBER : 10102-44-0
LAST UPDATED : 199712
DATA ITEMS CITED : 85
MOLECULAR FORMULA : N-O2
MOLECULAR WEIGHT : 46.01
WISWESSER LINE NOTATION : N O2
COMPOUND DESCRIPTOR : Mutagen
Reproductive Effector
Human
SYNONYMS/TRADE NAMES :
* Azote
* Azoto
* Nitrito
* Nitrogen dioxide
* Nitrogen peroxide
* RCRA waste number P078
* Stickstoffdioxid
* Stikstofdioxyde
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human
DOSE/DURATION : 200 ppm/1M
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AOHYA3 Annals of Occupational Hygiene. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
17,159,1974
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human - man
DOSE/DURATION : 6200 ppb/10M
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in pulmonary vascular resistance
REFERENCE :
KEKHA7 Koshu Eiseiin Kenkyu Hokoku. Bulletin of the Institute of Public
Health. (Kokuritsu Koshu Eiseiin, 4-6-1 Shirokanedai Minato-ku, Tokyo 108,
Japan) V.1- 1951- Volume(issue)/page/year: 17,337,1968
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Human - man
DOSE/DURATION : 90 ppm/40M
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - cough
Lungs, Thorax, or Respiration - dyspnea
Lungs, Thorax, or Respiration - other changes
REFERENCE :
JOCMA7 Journal of Occupational Medicine. (Chicago, IL) V.1-9, 1957-67.
For publisher information, see:JJOMDZ Volume(issue)/page/year: 8,301,1966
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 88 ppm/4H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine.
(Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
Volume(issue)/page/year: 10,418,1954
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1000 ppm/10M
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
Behavioral - changes in motor activity (specific assay)
REFERENCE :
JCTODH Journal of Combustion Toxicology. (Westport, CT) V.3-9, 1976-82.
Volume(issue)/page/year: 4,246,1977
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : 123 mg/m3/8H
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,160,1966
TYPE OF TEST : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Primate - monkey
DOSE/DURATION : 123 mg/m3/8H
TOXIC EFFECTS :
Sense Organs and Special Senses (Olfaction) - effect, not otherwise
specified
Sense Organs and Special Senses (Eye) - effect, not otherwise specified
Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
9,160,1966
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 315 ppm/15M
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
Sense Organs and Special Senses (Eye) - conjunctive irritation
REFERENCE :
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf
Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year:
23,457,1962
TYPE OF TEST : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 30 ppm/1H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - chronic pulmonary edema
Lungs, Thorax, or Respiration - respiratory stimulation
Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
10,220,1965
** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2 ppm/24H/14D-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - other transferases
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 15,23,1985
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5800 ug/m3/4H/17W-I
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
Volume(issue)/page/year: 15,53,1979
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 16 ppm/23H/74W-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - bronchiolar constriction
Lungs, Thorax, or Respiration - emphysema
Lungs, Thorax, or Respiration - changes in lung weight
REFERENCE :
ARDSBL American Review of Respiratory Disease. (American Lung Assoc., 1740
Broadway, New York, NY 10019) V.80- 1959- Volume(issue)/page/year:
121,541,1980
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5700 ug/m3/6H/26W-I
TOXIC EFFECTS :
Endocrine - other changes
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 26(12),79,1961
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 3 ppm/24H/39W-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Lungs, Thorax, or Respiration - changes in lung weight
Biochemical - Metabolism (Intermediary) - lipids including transport
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
26,156,1973
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 2 ppm/24H/1Y-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - changes in lung weight
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
17,181,1968
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 4 ppm/24H/14W-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - hepatic microsomal mixed oxidase (dealkylation, hydroxylation,
etc.)
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - cytochrome oxidases (including oxidative phosphorylation)
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 41,184,1986
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 8 ppm/24H/7D-C
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - other changes
Immunological Including Allergic - decrease in cellular immune response
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
AECTCV Archives of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
070944) V.1- 1973- Volume(issue)/page/year: 15,733,1986
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 5 ppm/24H/4W-C
TOXIC EFFECTS :
Liver - other changes
Biochemical - Metabolism (Intermediary) - other proteins
REFERENCE :
BECTA6 Bulletin of Environmental Contamination and Toxicology.
(Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ
07094) V.1- 1966- Volume(issue)/page/year: 40,139,1988
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 250 ppb/7H/7W-I
TOXIC EFFECTS :
Blood - changes in spleen
Immunological Including Allergic - decrease in cellular immune response
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 25,247,1988
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 20 ppm/24H/4D-C
TOXIC EFFECTS :
Endocrine - changes in spleen weight
Endocrine - changes in thymus weight
Immunological Including Allergic - decrease in humoral immune response
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 42,446,1987
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 10 ppm/2H/30W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
Blood - pigmented or nucleated red blood cells
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 19,154,1979
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 5800 ug/m3/4H/17W-I
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
Lungs, Thorax, or Respiration - respiratory depression
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv.
Toxicology of New Industrial Chemical Substances. For English translation,
see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-
Volume(issue)/page/year: 15,53,1979
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 15 ppm/24H/10W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder - other changes
Blood - changes in spleen
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - dehydrogenases
REFERENCE :
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
10,220,1965
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 3284 ug/m3/8H/26W-I
TOXIC EFFECTS :
Brain and Coverings - other degenerative changes
Biochemical - Enzyme inhibition, induction, or change in blood or tissue
levels - multiple enzyme effects
REFERENCE :
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068
Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 8,241,1975
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - hamster
DOSE/DURATION : 30 ppm/22H/36W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - structural or functional change in trachea
or bronchi
REFERENCE :
EXLRDA Experimental Lung Research. (Hemisphere Publishing, c/o Taylor &
Francis 1900 Frost Road, Suite 101, Bristol, PA 19007) V.1- 1980-
Volume(issue)/page/year: 11,179,1986
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Mammal - species unspecified
DOSE/DURATION : 10 ppm/4H/15W-I
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
Lungs, Thorax, or Respiration - other changes
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 73,241,1994
** REPRODUCTIVE DATA **
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 10 mg/m3/6H
SEX/DURATION : female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - weaning or lactation index (e.g., #
alive at weaning per # alive at day 4)
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
7,785,1985
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 85 ug/m3/24H
SEX/DURATION : female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
e.g., stunted fetus)
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 42(12),22,1977
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 800 ug/m3/24H
SEX/DURATION : female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
before birth)
REFERENCE :
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O
Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
Volume(issue)/page/year: 42(12),22,1977
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 2360 ug/m3/12H
SEX/DURATION : female 12 week(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - menstrual cycle changes or disorders
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
REFERENCE :
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA.
(Springfield, VA) 1964-71. Discontinued. Volume(issue)/page/year:
36(7-9),178,1971
TYPE OF TEST : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - rat
DOSE : 100 ug/m3/6H
SEX/DURATION : female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - behavioral
REFERENCE :
NTOTDY Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8,
1981-86. For publisher information, see NETEEC. Volume(issue)/page/year:
7,785,1985
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Inhalation
SPECIES OBSERVED : Rodent - mouse
DOSE : 22 ppm
SEX/DURATION : female 7-18 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
gain)
Reproductive - Effects on Newborn - behavioral
REFERENCE :
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR
72203) V.1- 1979- Volume(issue)/page/year: 9,545,1988
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 6 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,119,1984
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 5 ppm
REFERENCE :
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E.
11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year:
11,65,1988
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Salmonella typhimurium
DOSE/DURATION : 50 ppm
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 192,239,1987
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 198 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 162,1,1986
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 297 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 162,1,1986
TYPE OF TEST : Unscheduled DNA synthesis
ROUTE OF EXPOSURE : Inhalation
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 30 ppm/1H
REFERENCE :
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St.,
Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 27,352,1982
TYPE OF TEST : Cytogenetic analysis
ROUTE OF EXPOSURE : Inhalation
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 27 ppm/3H (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,119,1984
TYPE OF TEST : Mutation in mammalian somatic cells
ROUTE OF EXPOSURE : Inhalation
TEST SYSTEM : Rodent - rat
DOSE/DURATION : 15 ppm/3H (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,119,1984
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 10 ppm
REFERENCE :
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
Volume(issue)/page/year: 11,37,1990
TYPE OF TEST : Cytogenetic analysis
TEST SYSTEM : Rodent - hamster Fibroblast
DOSE/DURATION : 10 ppm/10M (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,303,1981
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 5 ppm/10M (Continuous)
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,303,1981
*** REVIEWS ***
ACGIH TLV-Not classifiable as a human carcinogen
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-STEL 9.4 mg/m3 (5 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
ACGIH TLV-TWA 5.6 mg/m3 (3 ppm)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
TLV/BEI,1997
TOXICOLOGY REVIEW
ANAEA3 Annals of Allergy. (American College of Allergists, POB 20671,
Bloomington, MN 55420) V.1- 1943- Volume(issue)/page/year: 35,165,1975
TOXICOLOGY REVIEW
FEPRA7 Federation Proceedings, Federation of American Societies for
Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
Volume(issue)/page/year: 35,89,1976
TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: PB228-002
TOXICOLOGY REVIEW
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher
information, see JTCTDW. Volume(issue)/page/year: 7,145,1974
TOXICOLOGY REVIEW
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
16,903,1968
TOXICOLOGY REVIEW
NTIS** National Technical Information Service. (Springfield, VA 22161)
Formerly U.S. Clearinghouse for Scientific & Technical Information.
Volume(issue)/page/year: CONF-691001
TOXICOLOGY REVIEW
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St.,
NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year:
12,522,1966
TOXICOLOGY REVIEW
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)
Volume(issue)/page/year: 272,1,1941
*** U.S. STANDARDS AND REGULATIONS ***
MSHA STANDARD:air-CL 5 ppm (9 mg/m3)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices
(BEIs) booklet issues by American Conference of Governmental Industrial
Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year:
3,185,1971
OSHA PEL (Gen Indu):CL 5 ppm (9 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1910.1000,1994
OSHA PEL (Construc):CL 5 ppm (9 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1926.55,1994
OSHA PEL (Shipyard):CL 5 ppm (9 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
29,1915.1000,1993
OSHA PEL (Fed Cont):CL 5 ppm (9 mg/m3)
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt.
of Documents, Washington, DC 20402) Volume(issue)/page/year:
41,50-204.50,1994
*** OCCUPATIONAL EXPOSURE LIMITS ***
OEL-ARAB Republic of Egypt:TWA 3 ppm (6 mg/m3) JAN 1993
OEL-DENMARK:TWA 3 ppm (5.6 mg/m3) JAN 1993
OEL-DENMARK:TWA 5 ppm (9.4 mg/m3) JAN 1993
OEL-FINLAND:TWA 3 ppm (6 mg/m3);STEL 6 ppm (12 mg/m3) JAN 1993
OEL-FRANCE:STEL 3 ppm (6 mg/m3) JAN 1993
OEL-GERMANY:TWA 5 ppm (9 mg/m3) JAN 1993
OEL-THE NETHERLANDS:TWA 2 ppm (4 mg/m3) JAN 1993
OEL-THE PHILIPPINES:TWA 5 ppm (9 mg/m3) JAN 1993
OEL-POLAND:TWA 5 mg/m3;STEL 10 mg/m3 JAN 1993
OEL-SWEDEN:TWA 2 ppm (4 mg/m3);STEL 5 ppm (13 mg/m3) JAN 1993
OEL-SWITZERLAND:TWA 3 ppm (6 mg/m3);STEL 6 ppm (12 mg/m3) JAN 1993
OEL-THAILAND:TWA 5 ppm (9 mg/m3) JAN 1993
OEL-TURKEY:TWA 5 ppm (9 mg/m3) JAN 1993
OEL-UNITED KINGDOM:TWA 3 ppm (5 mg/m3);STEL 5 ppm (9 mg/m3) JAN 1993
OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV
OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH RECOMMENDED EXPOSURE LEVEL (REL) :
NIOSH REL TO NITROGEN DIOXIDE-air:STEL 1 ppm
REFERENCE :
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of
Health, Education, and Welfare, Reports and Memoranda.
Volume(issue)/page/year: DHHS #92-100,1992
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOHS - National Occupational Hazard Survey (1974)
NOHS Hazard Code - 50870
No. of Facilities: 424 (estimated)
No. of Industries: 16
No. of Occupations: 19
No. of Employees: 11419 (estimated)
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - 50870
No. of Facilities: 94 (estimated)
No. of Industries: 5
No. of Occupations: 24
No. of Employees: 18737 (estimated)
No. of Female Employees: 1773 (estimated)
*** STATUS IN U.S. ***
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JUNE 1998
NIOSH Analytical Method, 1994: Nitric oxide and nitrogen dioxide, 6014
OSHA ANALYTICAL METHOD #ID-109
OSHA ANALYTICAL METHOD #ID-182
*** END OF RECORD ***