*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RA0802000
CHEMICAL NAME           : Nitrous acid, t-butyl ester
CAS REGISTRY NUMBER     : 540-80-7
BEILSTEIN REFERENCE NO. : 1209339
REFERENCE               : 4-01-00-01622 (Beilstein Handbook Reference)
LAST UPDATED            : 199709
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C4-H9-N-O2
MOLECULAR WEIGHT        : 103.14
WISWESSER LINE NOTATION : ONOX1&1&1
COMPOUND DESCRIPTOR     : Mutagen
SYNONYMS/TRADE NAMES :
   * tert-Butyl nitrite
   * alpha,alpha-Dimethylethyl nitrite
   * 1,1-Dimethylethyl nitrite
   * Nitrous acid, 1,1-dimethylethyl ester
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 308 mg/kg
TOXIC EFFECTS :
   Liver - other changes
   Blood - methemoglobinemia-carboxyhemoglobin
REFERENCE :
   RCSADO Research Communications in Substances Abuse.  (PJD Pub. Ltd., P.O.Box
   966, Westbury, NY 11590) V.1-    1980-  Volume(issue)/page/year: 3,233,1982
 
TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10852 ppm/1H
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Lungs, Thorax, or Respiration - cyanosis
   Kidney, Ureter, Bladder - urine volume increased
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year:
   1,448,1981
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 187 mg/kg
TOXIC EFFECTS :
   Liver - other changes
REFERENCE :
   RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD
   Pub. Ltd., P.O. Box 966, Westbury, NY 11590)  V.1-    1970-
   Volume(issue)/page/year: 26,75,1979
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1000 ppm/7H/60D-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - changes in lung weight
   Liver - changes in liver weight
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - dehydrogenases
REFERENCE :
   JJATDK JAT, Journal of Applied Toxicology.  (John Wiley & Sons Ltd., Baffins
   Lane, Chichester, W. Sussex PO19 1UD, UK)  V.1-    1981-
   Volume(issue)/page/year: 5,134,1985
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 10 umol/plate
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   35,3847,1986
 
                            *** END OF RECORD ***