*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RA5391000
CHEMICAL NAME           : 2,10,12,16,18-Nonadecapentaenoic acid,
                          19-(3,6-dihydro-3-methyl-6-oxo-2H-pyran-2-yl)-
                          3,5,7,9,11,15,17-heptamethyl-6-hydroxy-8-oxo-
CAS REGISTRY NUMBER     : 87081-36-5
LAST UPDATED            : 199401
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C32-H46-O6
MOLECULAR WEIGHT        : 526.78
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Jildamycin
   * Leptomycin A
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 10 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- ,  Berdy, J., Boca
   Raton, FL, CRC Press, 1980-  Volume(issue)/page/year: 13(3),203,1987
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Yeast - Schizosaccharomyces pombe
DOSE/DURATION           : 10 ug/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 38,1573,1985
 
TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Yeast - Schizosaccharomyces pombe
DOSE/DURATION           : 10 ug/L
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 38,1573,1985
 
                            *** END OF RECORD ***