*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RA8439000
CHEMICAL NAME           : 2,4,6,8-Nonatetraenamide,
                          3,7-dimethyl-N-ethyl-9-(4-methoxy-2,3,6-trimethylphen
                          yl)-, (all-E)-
CAS REGISTRY NUMBER     : 56281-36-8
BEILSTEIN REFERENCE NO. : 2169960
LAST UPDATED            : 199612
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C23-H31-N-O2
MOLECULAR WEIGHT        : 353.55
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   *   (all-E)-N-Ethyl-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8
     -nonatetraenamide
   * Molrelinid
   * Motretinid
   * Motretinide
   * Ro 11-1430
   * Tasmaderm
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2478 mg/kg/2W-I
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   YHHPAL Yaoxue Xuebao.  Acta Pharmaceutica Sinica.  Pharmaceutical Journal.
   (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep.
   China)  V.1-    1953-    Suspended 1966-78.  Volume(issue)/page/year:
   17,331,1982
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE                    : 350 mg/kg
SEX/DURATION            : female 8 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - other developmental
   abnormalities
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   95,122,1988

                          *** STATUS IN U.S. ***
 
   EPA GENETOX PROGRAM 1988, Negative: Cell transform.-C3H/10T1/2

 
                            *** END OF RECORD ***