*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : RB5935000 CHEMICAL NAME : 6a-alpha-Noraporphine-2,9-diol, 1,10-dimethoxy- CAS REGISTRY NUMBER : 5890-18-6 LAST UPDATED : 198208 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C18-H19-N-O4 MOLECULAR WEIGHT : 313.38 WISWESSER LINE NOTATION : T C6666 1A Q KM&TT&J EO1 FQ PQ QO1 COMPOUND DESCRIPTOR : Drug Natural Product SYNONYMS/TRADE NAMES : * 4H-Dibenzo(de,g)quinoline-2,9-diol, 5,6,6a,7-tetrahydro-1,10-dimethoxy- * Dimethoxy-1,10 dihydroxy-2,9 nor-aporphine * 1,10-Dimethoxy-6a-alpha-noraporphine-2,9-diol * Laurolitsine * Norboldine * (+)-Norboldine *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 450 mg/kg TOXIC EFFECTS : Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 170 mg/kg TOXIC EFFECTS : Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980 *** END OF RECORD ***