*** CHEMICAL IDENTIFICATION *** RTECS NUMBER : RB6025000 CHEMICAL NAME : 6a-alpha-Noraporphin-9-ol, 1,2,10-trimethoxy- CAS REGISTRY NUMBER : 128-76-7 LAST UPDATED : 198208 DATA ITEMS CITED : 3 MOLECULAR FORMULA : C19-H21-N-O4 MOLECULAR WEIGHT : 327.41 WISWESSER LINE NOTATION : T C6666 1A Q KM&TT&J EO1 FQ PO1 QO1 COMPOUND DESCRIPTOR : Drug Natural Product SYNONYMS/TRADE NAMES : * 4H-Dibenzo(de,g)quinolin-9-ol, 5,6,6a,7-tetrahydro-1,2,10-trimethoxy-, (S)- * Laurotetanin * Laurotetanine * (+)-Laurotetanine * Litsoeine * 1,2,10-Trimethoxy-6a-alpha-noraporphin-6-ol *** HEALTH HAZARD DATA *** ** ACUTE TOXICITY DATA ** TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 450 mg/kg TOXIC EFFECTS : Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 170 mg/kg TOXIC EFFECTS : Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 90 mg/kg TOXIC EFFECTS : Cardiac - change in rate Vascular - BP lowering not characterized in autonomic section Lungs, Thorax, or Respiration - other changes REFERENCE : APFRAD Annales Pharmaceutiques Francaises. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1943- Volume(issue)/page/year: 38,537,1980 *** END OF RECORD ***