*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RC5532500
CHEMICAL NAME           : 17-Norkauran-18-oic acid, 13-methyl-16-oxo-,
                          (4-alpha,8-beta,13-beta)-
CAS REGISTRY NUMBER     : 27975-19-5
LAST UPDATED            : 199703
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C20-H30-O3
MOLECULAR WEIGHT        : 318.50
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Isosteviol
   * (4-alpha,8-beta,13-beta)-13-Methyl-16-oxo-17-norkauran-18-oic acid
   * 17-Nor-8-beta,13-beta-kauran-18-oic acid, 13-methyl-16-oxo-
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi.  (Chinese Pharmacological
   Society, 27 Tai-Ping Road, Beijing 100850, China)  V.1-    1986-
   Volume(issue)/page/year: 8,33,1994
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 671 mg/kg
TOXIC EFFECTS :
   Vascular - regional or general arteriolar or venous dilation
   Liver - other changes
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi.  (Chinese Pharmacological
   Society, 27 Tai-Ping Road, Beijing 100850, China)  V.1-    1986-
   Volume(issue)/page/year: 8,33,1994
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 503 mg/kg
TOXIC EFFECTS :
   Vascular - regional or general arteriolar or venous dilation
   Liver - other changes
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi.  (Chinese Pharmacological
   Society, 27 Tai-Ping Road, Beijing 100850, China)  V.1-    1986-
   Volume(issue)/page/year: 8,33,1994
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5060 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi.  (Chinese Pharmacological
   Society, 27 Tai-Ping Road, Beijing 100850, China)  V.1-    1986-
   Volume(issue)/page/year: 8,33,1994
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1070 mg/kg
TOXIC EFFECTS :
   Vascular - regional or general arteriolar or venous dilation
   Liver - other changes
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi.  (Chinese Pharmacological
   Society, 27 Tai-Ping Road, Beijing 100850, China)  V.1-    1986-
   Volume(issue)/page/year: 8,33,1994
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 612 mg/kg
TOXIC EFFECTS :
   Vascular - regional or general arteriolar or venous dilation
   Liver - other changes
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi.  (Chinese Pharmacological
   Society, 27 Tai-Ping Road, Beijing 100850, China)  V.1-    1986-
   Volume(issue)/page/year: 8,33,1994
 
                            *** END OF RECORD ***