*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RC8960080
CHEMICAL NAME           : 19-Nor-17-alpha-pregna-4,9,11-trien-20-yn-3-one,
                          17-hydroxy-
CAS REGISTRY NUMBER     : 848-21-5
BEILSTEIN REFERENCE NO. : 6230207
LAST UPDATED            : 199706
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C20-H22-O2
MOLECULAR WEIGHT        : 294.42
COMPOUND DESCRIPTOR     : Reproductive Effector
                          Human
                          Hormone
SYNONYMS/TRADE NAMES :
   * 17-alpha-Ethynyl-17-beta-hydroxyestra-4,9,11-trien-3-one
   * 17-Hydroxy-19-nor-17-alpha-pregna-4,9,11-trien-20-yn-3-one
   * Norgestrienone
   * 19-Norpregna-4,9,11-trien-20-yn-3-one, 17-hydroxy-, (17-alpha)-
   * Ogyline
   * Planor
   * R 2010
   * RU 2010
 
                       *** HEALTH HAZARD DATA ***
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Human - woman
DOSE                    : 1168 ug/kg
SEX/DURATION            : female 52 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - menstrual cycle changes or disorders
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 18,411,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Human - woman
DOSE                    : 1642 ug/kg
SEX/DURATION            : female 52 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 18,429,1978
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Human - woman
DOSE                    : 1 mg/kg
SEX/DURATION            : female 36 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 20,511,1979
 
                            *** END OF RECORD ***