*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RC8964200
CHEMICAL NAME           : 19-Nor-17-alpha-pregn-4-en-20-yne-3-beta,17-diol
                          mixed with 3-methoxy-17-alpha-19-
                          norpregna-1,3,5(10)-trien-20-yn-17-ol
CAS REGISTRY NUMBER     : 8056-92-6
LAST UPDATED            : 199509
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C24-H32-O4.C21-H26-O2
MOLECULAR WEIGHT        : 695.03
WISWESSER LINE NOTATION : L E5 B666TTT&J E1 FQ F1UU1 OO1 &Q1UU1Q
COMPOUND DESCRIPTOR     : Tumorigen
                          Human
SYNONYMS/TRADE NAMES :
   * Ethynodiol mixed with mestranol
   * Mestranol mixed with ethynodiol
   * Ovulen
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 220 ug/kg/2W
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   ARDEAC Archives of Dermatology.  (AMA, 535 N. Dearborn St., Chicago, IL
   60610)  V.82-    1960-  Volume(issue)/page/year: 113,333,1977
 
                          ** TUMORIGENIC DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 63504 ug/kg/12Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 1,273,1980

                              *** REVIEWS ***
 
   TOXICOLOGY REVIEW
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 21,225,1980

 
                            *** END OF RECORD ***