*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RF7174000
CHEMICAL NAME           : Ochratoxin
CAS REGISTRY NUMBER     : 37203-43-3
LAST UPDATED            : 199503
DATA ITEMS CITED        : 4
WISWESSER LINE NOTATION : T66 BVOT&J D1 GG IVMYVQ1R& JQ
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 20 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Liver - hepatitis (hepatocellular necrosis), zonal
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   19FKA3 "Biochemistry of Some Foodborne Microbial Toxins, Papers Presented at
   the Symposium on Microbial Toxins, New York, 1966," Mateles, R.I., and G.N.
   Wogan, eds., Cambridge, MA, MIT Press, 1967  Volume(issue)/page/year:
   -,153,1967
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - pig
DOSE                    : 35 ug/kg
SEX/DURATION            : female 21-28 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Effects on Embryo or Fetus - other effects to embryo
REFERENCE :
   BVJOA9 British Veterinary Journal.  (Bailliere Tindall, 33 The Avenue,
   Eastbourne BN21 3UN, UK) V.105-    1949-  Volume(issue)/page/year:
   133,412,1977
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 560 mg/kg/14D (Continuous)
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   32,471,1994
 
TYPE OF TEST            : Sperm Morphology
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 560 mg/kg/14D (Continuous)
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   32,471,1994
 
                            *** END OF RECORD ***