*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RH0367000
CHEMICAL NAME           : Octanoic acid,
                          2-(4-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyrano
                          syl)oxy)-1,2,3,4,6,11-
                          hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-na
                          phthacenyl)-2-oxoethyl ester, hydrochloride, (2S-cis)
CAS REGISTRY NUMBER     : 51898-39-6
LAST UPDATED            : 199106
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C35-H43-N-O12.Cl-H
MOLECULAR WEIGHT        : 706.25
WISWESSER LINE NOTATION : L E6 C666 BV MVT&&&J DQ HV1OV7 HQ KQ RO1 FO- FT6OTJ
                          B1 CQ DZ &GH
COMPOUND DESCRIPTOR     : Drug
                          Mutagen
SYNONYMS/TRADE NAMES :
   * Adriamycin-14-octanoate hydrochloride
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 19 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   31TFAO "Progress in Chemotherapy, Proceedings of the 8th International
   Congress on Chemotherapy, Athens, Greece, 1973," Daikos, G.K. ed., Athens,
   Greece, Hellenic Soc. for Chemotherapy, 1974  Volume(issue)/page/year:
   3,987,1974
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : DNA damage
TEST SYSTEM             : Mammal - species unspecified Lymphocyte
DOSE/DURATION           : 52 umol/L
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 32,315,1977
 
                            *** END OF RECORD ***