*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RH6300000
CHEMICAL NAME           : L-threo-D-galacto-Octopyranoside, methyl
                          7-chloro-6,7,8-trideoxy-6-(1-methyl-4-propyl-L-2-
                          pyrrolidinecarboxamido)-1-thio-, trans-alpha-
CAS REGISTRY NUMBER     : 18323-44-9
LAST UPDATED            : 199606
DATA ITEMS CITED        : 5
MOLECULAR FORMULA       : C18-H33-Cl-N2-O5-S
MOLECULAR WEIGHT        : 425.04
WISWESSER LINE NOTATION : T6OTJ BS1 CQ DQ EQ FYYG1&MV- BT5NTJ A1 D3
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * 7-CDL
   * Chlolincocin
   * 7-Chlorodeoxylincomycin
   * 7(S)-Chloro-7-deoxylincomycin
   * 7-Chlorolincomycin
   * Cleocin
   * Clindamycin
   * Clindamycine
   * Clinimycin
   * Dalacin C
   * Sobelin
   * U-21,251
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2618 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   18,185,1971
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   RMVEAG Recueil de Medecine Veterinaire.  (Masson Pub. USA, Inc., Year Book
   Medical Pub., 35 E. Wacker Dr., Chicago IL 60601)  V.1-    1824-
   Volume(issue)/page/year: 156,915,1980
 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 1 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 34,794,1984
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 330 mg/kg/33D-I
TOXIC EFFECTS :
   Gastrointestinal - other changes
REFERENCE :
   ANTBAL Antibiotiki.  (Moscow, USSR)  V.1-29, 1956-84.  For publisher
   information, see AMBIEH.  Volume(issue)/page/year: 28,18,1983

         *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***

NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
   NOES - National Occupational Exposure Survey (1983)
     NOES Hazard Code - X3191
       No. of Facilities: 445 (estimated)
       No. of Industries: 1
       No. of Occupations: 7
       No. of Employees: 21575 (estimated)
       No. of Female Employees: 17442 (estimated)

 
                            *** END OF RECORD ***