*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : RH6314000
CHEMICAL NAME : D-erythro-D-Galacto-octopyranoside,
methyl-6,8-dideoxy-6-(1-methyl-4-propyl-L-2-
pyrrolidinecarboxamido)-1-thio-, trans-alpha-
CAS REGISTRY NUMBER : 154-21-2
BEILSTEIN REFERENCE NO. : 0707677
LAST UPDATED : 199706
DATA ITEMS CITED : 9
MOLECULAR FORMULA : C18-H34-N2-O6-S
MOLECULAR WEIGHT : 406.60
WISWESSER LINE NOTATION : T6OTJ BS1 CQ DQ EQ FYYQ1&MV- BT5NTJ A1 D3
COMPOUND DESCRIPTOR : Drug
Mutagen
Natural Product
SYNONYMS/TRADE NAMES :
* Cillimycin
* Jiemycin
* Lincolcina
* Lincomycin
* Lincomycin A
* Lincomycine
* NSC-70731
* U 10,149 A
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
eds., Washington, DC, American Soc. for Microbiology, 1978
Volume(issue)/page/year: 1,186,1978
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 1900 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Blood - other changes
REFERENCE :
ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me
zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988-
Volume(issue)/page/year: 35(2),40,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Subcutaneous
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 9778 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E.
First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year:
18,185,1971
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 13900 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Blood - other changes
REFERENCE :
ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me
zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988-
Volume(issue)/page/year: 35(2),40,1990
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 1 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI)
1961-70. For publisher information, see AMACCQ. Volume(issue)/page/year:
-, 554,1962
TYPE OF TEST : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE : Intramuscular
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : 200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RMVEAG Recueil de Medecine Veterinaire. (Masson Pub. USA, Inc., Year Book
Medical Pub., 35 E. Wacker Dr., Chicago IL 60601) V.1- 1824-
Volume(issue)/page/year: 156,915,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - guinea pig
DOSE/DURATION : 1800 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS
Blood - other changes
REFERENCE :
ANKHEW Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. (V/O Me
zhdunarodnaya Kniga, 113095 Moskow, USSR) V.33- 1988-
Volume(issue)/page/year: 35(2),40,1990
*** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA ***
NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA :
NOES - National Occupational Exposure Survey (1983)
NOES Hazard Code - X3678
No. of Facilities: 147 (estimated)
No. of Industries: 2
No. of Occupations: 4
No. of Employees: 1414 (estimated)
No. of Female Employees: 161 (estimated)
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay
*** END OF RECORD ***