*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RJ9220000
CHEMICAL NAME           : Oleandomycin
CAS REGISTRY NUMBER     : 3922-90-5
LAST UPDATED            : 199012
DATA ITEMS CITED        : 8
MOLECULAR FORMULA       : C35-H61-N-O12
MOLECULAR WEIGHT        : 687.97
WISWESSER LINE NOTATION : T-14-VO GVXTJ C1 D1 EQ F1 J1 L1 N1 H-& BT3OX CHJ& KO-
                          BT6OTJ CQ DN1&1 F1& MO- FT6OTJ B1 CQ DO
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Amimycin
   * Antibiotic PA-105
   * Oleandomycine
   * PA 775
   * Romicil
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 6700 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AMPMAR Archives des Maladies Professionnelles de Medecine du Travail et de
   Securite Sociale.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.7-    1946-
   Volume(issue)/page/year: 39,259,1978
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 gm/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Behavioral - ataxia
REFERENCE :
   HMACAX Helvetica Medica Acta.  (Basel, Switzerland)  V.1-37, 1934-1974. For
   publisher information, see SMWOAS.  Volume(issue)/page/year: 23,714,1956
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 440 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Behavioral - ataxia
REFERENCE :
   HMACAX Helvetica Medica Acta.  (Basel, Switzerland)  V.1-37, 1934-1974. For
   publisher information, see SMWOAS.  Volume(issue)/page/year: 23,714,1956
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8200 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Behavioral - ataxia
REFERENCE :
   HMACAX Helvetica Medica Acta.  (Basel, Switzerland)  V.1-37, 1934-1974. For
   publisher information, see SMWOAS.  Volume(issue)/page/year: 23,714,1956
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Behavioral - ataxia
REFERENCE :
   HMACAX Helvetica Medica Acta.  (Basel, Switzerland)  V.1-37, 1934-1974. For
   publisher information, see SMWOAS.  Volume(issue)/page/year: 23,714,1956
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 460 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds.,
   Tokyo, Univ. of Tokyo Press, 1967  Volume(issue)/page/year: -,475,1967
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Behavioral - ataxia
REFERENCE :
   HMACAX Helvetica Medica Acta.  (Basel, Switzerland)  V.1-37, 1934-1974. For
   publisher information, see SMWOAS.  Volume(issue)/page/year: 23,714,1956
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2343 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Behavioral - ataxia
REFERENCE :
   HMACAX Helvetica Medica Acta.  (Basel, Switzerland)  V.1-37, 1934-1974. For
   publisher information, see SMWOAS.  Volume(issue)/page/year: 23,714,1956
 
                            *** END OF RECORD ***