*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RK0177530
CHEMICAL NAME           : Olean-12-ene-28,29-dioic acid,
                          2,23-dihydroxy-3-((4-O-beta-D-glucopyranosyl-beta-D-
                          xylopyranosyl)oxy)-, 29-methyl ester,
                          (2-beta,3-beta,4-alpha,20-beta)-
CAS REGISTRY NUMBER     : 65497-07-6
LAST UPDATED            : 198706
DATA ITEMS CITED        : 4
MOLECULAR FORMULA       : C42-H66-O16
MOLECULAR WEIGHT        : 827.08
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Phytolaccasaponin E
   * Phytolaccoside E
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 42300 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   SYHJAM Saengyak Hakhoechi.  Journal of the Society of Pharmacognosy. (Hanguk
   Saengyak Hakhoe, c/o Natural Products Institute, Seoul National Univ., 28
   Yunkeon-Dong, Chong-ro-ku, Seoul 110, Korea)  1970- Volume(issue)/page/year:
   10,73,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - hair
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   SHZAAY Shoyakugaku Zasshi.  Journal of Pharmacognosy.  (Nippon Shoyaku
   Gakkai, c/o Nippon Gakkai Jimu Senta, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113,
   Japan)  V.6-    1952-  Volume(issue)/page/year: 33,111,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 486 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - hair
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   SHZAAY Shoyakugaku Zasshi.  Journal of Pharmacognosy.  (Nippon Shoyaku
   Gakkai, c/o Nippon Gakkai Jimu Senta, 2-4-16 Yayoi, Bunkyo-ku, Tokyo 113,
   Japan)  V.6-    1952-  Volume(issue)/page/year: 33,111,1979
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 23600 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   SYHJAM Saengyak Hakhoechi.  Journal of the Society of Pharmacognosy. (Hanguk
   Saengyak Hakhoe, c/o Natural Products Institute, Seoul National Univ., 28
   Yunkeon-Dong, Chong-ro-ku, Seoul 110, Korea)  1970- Volume(issue)/page/year:
   10,73,1979
 
                            *** END OF RECORD ***