*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RM3201100
CHEMICAL NAME           : Orotic acid, compd. with
                          7-chloro-4-((4-(diethylamino)-1-methylbutyl)amino)qui
                          noline (2:1)
CAS REGISTRY NUMBER     : 16301-30-7
LAST UPDATED            : 198502
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C18-H26-Cl-N3.2C5-H4-N2-O4
MOLECULAR WEIGHT        : 632.14
SYNONYMS/TRADE NAMES :
   * Chloroquine diorotate
   * Kidola
   * Kidora
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1130 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 7,753,1973
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 198 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 7,753,1973
 
                            *** END OF RECORD ***