*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : RN8925000
CHEMICAL NAME : 7-Oxabicyclo(4.1.0)hept-3-ene-2,5-dione,
3-hydroxy-4-methyl-, (1R)-
CAS REGISTRY NUMBER : 121-40-4
LAST UPDATED : 199409
DATA ITEMS CITED : 3
MOLECULAR FORMULA : C7-H6-O4
MOLECULAR WEIGHT : 154.13
WISWESSER LINE NOTATION : T36 BO DV GV EUTJ E1 FQ
COMPOUND DESCRIPTOR : Drug
Mutagen
Natural Product
SYNONYMS/TRADE NAMES :
* 2-Hydroxy-3-methyl-1,4-benzoquinone 5,6-epoxide
* 5,6-Epoxy-3-hydroxy-p-toluquinone
* (1R)-3-Hydroxy-4-methyl-7-oxabicyclo(4.1.0)hept-3-ene-2,5-dione
* 7-Oxabicyclo(4.1.0)hept-3-ene-2,5-dione, 3-hydroxy-4-methyl-,
stereoisomer
* Terreic acid
* (-)-Terreic acid
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 75 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JJANAX Japanese Journal of Antibiotics. (Japan Antibiotics Research Assoc.,
2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan) V.21- 1968-
Volume(issue)/page/year: 33,320,1980
** MUTATION DATA **
TYPE OF TEST : DNA adduct
ROUTE OF EXPOSURE : Intraperitoneal
TEST SYSTEM : Rodent - mouse
DOSE/DURATION : 250 mg/kg
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 10,249,1982
TYPE OF TEST : DNA adduct
TEST SYSTEM : Rodent - mouse Liver
DOSE/DURATION : 200 mg/L
REFERENCE :
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 10,249,1982
*** END OF RECORD ***