*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RN6803000
CHEMICAL NAME           : 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid,
                          3-(2-hydroxyethylidine)-7-oxo-, sodium salt,
                          (2R-(2-alpha,3Z,5-alpha))-
CAS REGISTRY NUMBER     : 57943-81-4
LAST UPDATED            : 199512
DATA ITEMS CITED        : 2
WISWESSER LINE NOTATION : T45 AN EOYTJ FU2Q GVO &-NA-
COMPOUND DESCRIPTOR     : Drug
                          Natural Product
SYNONYMS/TRADE NAMES :
   * Antibiotic MM 14151 sodium salt
   * Clavulanic acid sodium salt
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 30,77-27,1977
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JANTAJ Journal of Antibiotics.  (Japan Antibiotics Research Assoc., 2-20-8
   Kamiosaki, Shinagawa-ku, Tokyo, 141, Japan)  V.2-5, 1948-52;  V.21- 1968-
   Volume(issue)/page/year: 30,77-27,1977
 
                            *** END OF RECORD ***