*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : RO0610000
CHEMICAL NAME : 1,2,4-Oxadiazole,
5-amino-3-(2-(5-nitro-2-furyl)vinyl)- (E)-
CAS REGISTRY NUMBER : 28754-68-9
BEILSTEIN REFERENCE NO. : 1079486
LAST UPDATED : 199612
DATA ITEMS CITED : 10
MOLECULAR FORMULA : C8-H6-N4-O4
MOLECULAR WEIGHT : 222.18
WISWESSER LINE NOTATION : T5OJ BNW E1U1- ET5NO DN EHJ CZ
COMPOUND DESCRIPTOR : Mutagen
SYNONYMS/TRADE NAMES :
* trans-5-Amino-3-(2-(5-nitro-2-furyl)-vinyl)-1,2,4-oxadiazole
* 1,2,4-Oxadiazol-5-amine, 3-(2-(5-nitro-2-furanyl)ethenyl)-, (E)-
* SQ18506
*** HEALTH HAZARD DATA ***
** MUTATION DATA **
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 5 ug/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 164,9,1986
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 100 mg/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
27,2815,1978
TYPE OF TEST : Mutation test systems - not otherwise specified
TEST SYSTEM : Microorganism - not otherwise specified
DOSE/DURATION : 100 mg/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
27,2815,1978
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Mold - Neurospora crassa
DOSE/DURATION : 20 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 56,13,1977
TYPE OF TEST : Morphological transformation
TEST SYSTEM : Rodent - rat Embryo
DOSE/DURATION : 1 mg/L
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 1,323,1975
TYPE OF TEST : Host-mediated assay
TEST SYSTEM : Rodent - mouse Bacteria - Escherichia coli
DOSE/DURATION : 100 ug/kg/90M
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 164,9,1986
*** STATUS IN U.S. ***
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: N crassa-forward mutation; N
crassa-reversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S
cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion
*** END OF RECORD ***