*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RO2520000
CHEMICAL NAME           : Oxalic acid, bis(cyclohexylidenehydrazide)
CAS REGISTRY NUMBER     : 370-81-0
BEILSTEIN REFERENCE NO. : 2388004
REFERENCE               : 4-07-00-00025 (Beilstein Handbook Reference)
LAST UPDATED            : 199701
DATA ITEMS CITED        : 6
MOLECULAR FORMULA       : C14-H22-N4-O2
MOLECULAR WEIGHT        : 278.40
WISWESSER LINE NOTATION : L6YTJ AUNMVVMNU- AL6YTJ
COMPOUND DESCRIPTOR     : Mutagen
                          Reproductive Effector
SYNONYMS/TRADE NAMES :
   * Biscyclohexanone oxaldihydrazone
   * Cuprizone
   * Ethanedioic acid, bis(cyclohexylidene hydrazide)
 
                       *** HEALTH HAZARD DATA ***
 
                 ** OTHER MULTIPLE DOSE TOXICITY DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 29400 mg/kg/7W-C
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
   Related to Chronic Data - death
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   8,512,1966
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 20160 mg/kg/8W-C
TOXIC EFFECTS :
   Brain and Coverings - other degenerative changes
   Biochemical - Enzyme inhibition, induction, or change in blood or tissue
   levels - monoamine oxidase
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   20,386,1971
 
                          ** REPRODUCTIVE DATA **
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 24 gm/kg
SEX/DURATION            : female 3-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   8,512,1966
 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 40 gm/kg
SEX/DURATION            : female 3-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - stillbirth
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   8,512,1966
 
                            ** MUTATION DATA **
 
TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 14 gm/kg/14D (Continuous)
REFERENCE :
   EJBCAI European Journal of Biochemistry.  (Springer-Verlag New York, Inc.,
   Service Center, 44 Hartz Way, Secaucus, NJ 07094)  V.1-    1967-
   Volume(issue)/page/year: 47,313,1974

                          *** STATUS IN U.S. ***
 
   EPA TSCA Section 8(b) CHEMICAL INVENTORY

 
                            *** END OF RECORD ***