*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RP5776700
CHEMICAL NAME           : Oxayohimbanium,
                          3,4,5,6,16,17-hexahydro-16-(isobutoxycarbonyl)-19-met
                          hyl-, hydroxide, inner salt, (19-alpha)-
LAST UPDATED            : 198306
DATA ITEMS CITED        : 3
MOLECULAR FORMULA       : C24-H27-N2-O3
MOLECULAR WEIGHT        : 391.53
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * Isobutyl ester of serpentinic acid
   * Ph. 458
   * Serpentinic acid isobutyl ester
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 29 mg/kg
TOXIC EFFECTS :
   Behavioral - antipsychotic
   Behavioral - aggression
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 123,168,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 46500 ug/kg
TOXIC EFFECTS :
   Behavioral - antipsychotic
   Behavioral - aggression
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 123,168,1959
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 137 mg/kg
TOXIC EFFECTS :
   Behavioral - antipsychotic
   Behavioral - aggression
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 123,168,1959
 
                            *** END OF RECORD ***