*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RP5788694
CHEMICAL NAME           : 2H-1,3,2-Oxazaphosphorin-2-amine,
                          tetrahydro-N,3-bis(2-chloroethyl)-, 2-oxide, (S)-
CAS REGISTRY NUMBER     : 66849-33-0
BEILSTEIN REFERENCE NO. : 5802893
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C7-H15-Cl2-N2-O2-P
MOLECULAR WEIGHT        : 261.11
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   * (S)-N,3-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine  
   2-oxide
   * (-)-Ifosfamid
   * D-Ifosfamide
   * (-)-Ifosphamide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   34,293,1986
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 559 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 36,1493,1986
 
                            *** END OF RECORD ***