*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : RP5900000
CHEMICAL NAME : 2H-1,3,2-Oxazophosphorine,
2-(bis(2-chloroethyl)amino)-4-hydroperoxytetrahydro-,
2-oxide
CAS REGISTRY NUMBER : 39800-16-3
BEILSTEIN REFERENCE NO. : 0531579
LAST UPDATED : 199612
DATA ITEMS CITED : 12
MOLECULAR FORMULA : C7-H15-Cl2-N2-O4-P
MOLECULAR WEIGHT : 293.11
WISWESSER LINE NOTATION : T6MPOTJ BN2G2G FOQ
COMPOUND DESCRIPTOR : Drug
Mutagen
SYNONYMS/TRADE NAMES :
* ASTA 6496
* 2-(Bis(2-chloroethyl)amino)-4-hydroperoxytetrahydro-2H-1,3,2-oxazaphosph
orine
* Hydroperoxide,
2-(bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorin-4-yl-,
P-oxide
* 4-Hydroperoxycyclophosphamide
* 4-Hydroperoxyphosphamide
* NSC 181815
* 4-Peroxy-cpa
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 76040 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCISP* National Cancer Institute Screening Program Data Summary,
Developmental Therapeutics Program. (Bethesda, MD 20205)
Volume(issue)/page/year: JAN1986
** MUTATION DATA **
TYPE OF TEST : Mutation in microorganisms
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 500 umol/L
REFERENCE :
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub.,
1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
Volume(issue)/page/year: 3,637,1977
TYPE OF TEST : DNA repair
TEST SYSTEM : Bacteria - Escherichia coli
DOSE/DURATION : 200 umol/L
REFERENCE :
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin,
Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7.
Volume(issue)/page/year: 92,177,1978
TYPE OF TEST : DNA damage
TEST SYSTEM : Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 100 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
39,1,1982
TYPE OF TEST : Unscheduled DNA synthesis
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 15 mg/L
REFERENCE :
EXHMA6 Experimental Hematology (New York). (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1973-
Volume(issue)/page/year: 13,1014,1985
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Human Lymphocyte
DOSE/DURATION : 3 mg/L
REFERENCE :
EXHMA6 Experimental Hematology (New York). (Springer-Verlag New York, Inc.,
Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1973-
Volume(issue)/page/year: 13,1014,1985
TYPE OF TEST : DNA inhibition
TEST SYSTEM : Rodent - rat Cells - not otherwise specified
DOSE/DURATION : 6 umol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
39,191,1982
TYPE OF TEST : Host-mediated assay
TEST SYSTEM : Rodent - rat Yeast - Saccharomyces cerevisiae
DOSE/DURATION : 300 mg/kg
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland
Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year:
37,141,1981
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - mouse Leukocyte
DOSE/DURATION : 10 umol/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
33,1867,1984
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - mouse Leukocyte
DOSE/DURATION : 19 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 222,271,1989
TYPE OF TEST : Sister chromatid exchange
TEST SYSTEM : Rodent - mouse Leukocyte
DOSE/DURATION : 1 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE
Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 222,271,1989
TYPE OF TEST : DNA damage
TEST SYSTEM : Rodent - hamster Lung
DOSE/DURATION : 5 mg/L
REFERENCE :
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House,
Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year:
35,1163,1986
*** END OF RECORD ***