*** CHEMICAL IDENTIFICATION ***

RTECS NUMBER            : RP6159000
CHEMICAL NAME           : 2H-1,3,2-Oxazaphosphorine,
                          tetrahydro-2-(bis(2-chloroethyl)amino)-6-trifluoromet
                          hyl-, 2-oxide
CAS REGISTRY NUMBER     : 57165-71-6
BEILSTEIN REFERENCE NO. : 1002990
LAST UPDATED            : 199612
DATA ITEMS CITED        : 2
MOLECULAR FORMULA       : C8-H14-Cl2-F3-N2-O2-P
MOLECULAR WEIGHT        : 329.11
WISWESSER LINE NOTATION : T6MPOTJ BO BN2G2G DXFFF
COMPOUND DESCRIPTOR     : Drug
SYNONYMS/TRADE NAMES :
   *   2-(Bis(2-chloroethyl)amino)-6-trifluoromethyltetrahydro-2H-1,3,2-oxazaph
     osphorine 2-oxide
   * 6-Trifluoromethylcyclophosphamide
 
                       *** HEALTH HAZARD DATA ***
 
                        ** ACUTE TOXICITY DATA **
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 224 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 18,1106,1975
 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 18,1106,1975
 
                            *** END OF RECORD ***